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Uracil derivatives and analogs syntheses of 5 beta tri methylsilyl ethynyl uracil and 5 ethynyl uracil

, : Uracil derivatives and analogs syntheses of 5 beta tri methylsilyl ethynyl uracil and 5 ethynyl uracil. Journal of Heterocyclic Chemistry 19(3): 463-464

5-(.alpha.-Chlorovinyl)-2,4-dichloropyrimidine, on treatment with sodium methoxide in methanol, was converted to 2,4-dimethoxy-5-ethynylpyrimidine, which was silylated by t-butyl lithium and chlorotrimethylsilane to 2,4-dimethoxy-5-(.beta.-trimethylsilyl)ethynylpyrimidine, which on deblocking with trimethylsilyl iodide yielded 5-(.beta.-trimethylsilyl)ethylnyluracil, which on treatment with sodium hydroxide in methanol was converted to 5-ethylnyluracil.


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Thomas, K.; Thomson, A.J.; Wood, S.J.; Kingsland, C.R.; Vince, G.; Lewis-Jones, D.I., 2003: Endometrial integrin expression in women undergoing IVF and ICSI: a comparison of the two groups and fertile controls. Integrins are thought to play a vital role in implantation. Three integrins in particular (alpha(4)beta(1), alpha(v)beta(3) and alpha(1)beta(1)) are all present during the implantation window. Defects in their expression have been linked to tubal...

Frank, J.; Kelleher, D.K.; Lambert, C.; Thews, O.; Vaupel, P.; Biesalski, H.K., 2002: Involvement of oxidative injury in the enhancement of the antitumor effects of ALA-based photodynamic therapy by hyperthermia. Oxidative stress-related changes in tumors upon localized hyperthermia (HT), 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and their combination were examined following the observation that antitumor effects of ALA-PDT were significan...