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Uracil derivatives and analogs syntheses of 5 beta tri methylsilyl ethynyl uracil and 5 ethynyl uracil


, : Uracil derivatives and analogs syntheses of 5 beta tri methylsilyl ethynyl uracil and 5 ethynyl uracil. Journal of Heterocyclic Chemistry 19(3): 463-464

5-(.alpha.-Chlorovinyl)-2,4-dichloropyrimidine, on treatment with sodium methoxide in methanol, was converted to 2,4-dimethoxy-5-ethynylpyrimidine, which was silylated by t-butyl lithium and chlorotrimethylsilane to 2,4-dimethoxy-5-(.beta.-trimethylsilyl)ethynylpyrimidine, which on deblocking with trimethylsilyl iodide yielded 5-(.beta.-trimethylsilyl)ethylnyluracil, which on treatment with sodium hydroxide in methanol was converted to 5-ethylnyluracil.

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