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Use of nitrogen specific detector for gas liquid chromatographic determination of caramiphen in whole blood

, : Use of nitrogen specific detector for gas liquid chromatographic determination of caramiphen in whole blood. Journal of Pharmaceutical Sciences 69(11): 1353-1354

Caramiphen ethanedisulfonate (.beta.-diethylaminoethyl 1-phenylcyclopentane-1-carboxylate ethanedisulfonate) is an antitussive used as an active ingredient in cough/cold preparations. A sensitive GLC determination of caramiphen in whole blood was developed using a N-specific detector. The method permits the determination of levels of caramiphen as low as 2.5 ng/ml [human] blood, and provides sufficient sensitivity and reproducibility for clinical use.


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