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3 5 diphenyl 1h pyrazole derivatives vi. esters and 2 dialkylaminoethyl ethers of 12 hydroxy 2 phenylethyl 3 5 diphenyl 1h pyrazole and n n disubstituted 1 2 amino 2 phenylethyl 3 5 diphenyl 1h pyrazoles with depressant and platelet antiaggregating activities


, : 3 5 diphenyl 1h pyrazole derivatives vi. esters and 2 dialkylaminoethyl ethers of 12 hydroxy 2 phenylethyl 3 5 diphenyl 1h pyrazole and n n disubstituted 1 2 amino 2 phenylethyl 3 5 diphenyl 1h pyrazoles with depressant and platelet antiaggregating activities. Farmaco (Rome) 45(5): 511-526

The syntheses of 1-(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole 1 by reaction of 2-hydrazino-1-phenylethanol with dibenzoylmethane, of esters 2 and 2-dialkylaminoethyl ethers 3 starting from 1 as sodium salt and acyl chlorides or 2-chloroethyldialkylamines, respectively, as well as of N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1 H-pyrazoles 5 by reaction of secondary amines with the tosylate of 1, are described. Some of the above compounds showed a considerable sedative effect in mice and a remarkable platelet antiaggregating activity in vitro, as well as moderate local anesthetic, analgesic and antiinflammatory activities in mice and rats.

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