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3 5 diphenyl 1h pyrazole derivatives vii. esters 2 dialkylaminoethyl ethers and n substituted carbamates of 1 2 hydroxy 3 phenoxypropyl 3 5 diphenyl 1h pyrazole with depressant and platelet antiaggregating activities


, : 3 5 diphenyl 1h pyrazole derivatives vii. esters 2 dialkylaminoethyl ethers and n substituted carbamates of 1 2 hydroxy 3 phenoxypropyl 3 5 diphenyl 1h pyrazole with depressant and platelet antiaggregating activities. Farmaco (Rome) 45(5): 527-544

The syntheses of 1-(2-hydroxy-3-phenoxypropyl)-3,5-diphenyl-1H-pyrazole 2 by reaction of 1-hydrazino-3-phenoxy-2-propanol with dibenzoylmethane, of esters 3 and 2-dialkylaminoethyl ethers 4 starting from 2 as sodium salt and acyl chlorides or 2-chloroethyldialkylamines, respectively, as well as of N-aryl carbamates 5 by reaction of 2 with aryl isocyanates, are described. Some of the above compounds showed a considerable sedative effect in mice and a remarkable platelet antiaggregating activity in vitro, as well as moderate local anesthetic, analgesic and antiinflammatory activities in mice and rats.

US$29.90

PMID: 2222724


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