+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Acute toxic effect of sodium dichromate on metabolism

, : Acute toxic effect of sodium dichromate on metabolism. Archives of Toxicology 64(8): 644-649

The effect of sodium dichromate on cellular metabolism was investigated. Intraperitoneal injection of sodium dichromate into the rat (20 or 40 mg/kg) caused significant increases in serum lactate, pyruvate, and creatinine concentrations within 15 min after intoxication. Severe hyperglycemia occurred thereafter, as a result of increased hepatic glycogenolysis, which was seen in the first 2 h after dichromate. However, liver glycogen was resynthesized in 24h-fased rats after glucose refeeding. Dichromate decreased serum total amino acids, with a consequent increase in blood urea nitrogen (BUN) concentration. Unlike HgCl2 (2 mg/kg, i.p.), As2O3 (5 mg/kg, i.p.), and KCN (5 mg/kg, i.p.), dichromate showed the largest metabolic disturbance only in the early period after treatment. In addition, dichromate produced cyanosis, which appeared during the period of the accelerated glycolysis and breakdown of creatine phosphate. Regardless of chemical species, only the hexavalent chromium compounds had an effect on the cellular metabolism. Trivalent chromium compounds had no effect at all. These results suggest that dichromate possesses a characteristic dual action on cellular metabolism, which might be related to its metabolic fate.


PMID: 2090032

DOI: 10.1007/bf01974692

Other references

Howard, David W., 1991: A look at viscometry. Viscosity measurements help us understand flow behavior. Food Technology 45: 4

Villavicencio, E.; Rusoff, L.L.; Girouard, R.E.; Waters, W.H., 1968: Comparison of complete feed rations to a conventional ration for lactating cows. In a continuous trial for 110 days 16 Holstein cows with high yield were given long lucerne hay 30 and concentrate 70% separately or complete feeds of lucerne hay, chopped to 2.5 cm, 30 and concentrate 70%, cottonseed hulls 30 and concentrate 70%,...

Pickler, R.H.; Mauck, A.G.; Geldmaker, B., 1997: Bottle-feeding histories of preterm infants. To describe the bottle-feeding histories of preterm infants and determine physical indices related to and predictive of bottle-feeding initiation and progression. Ex post facto. Academic medical center. A convenience sample of 40 preterm infants w...

van, d.Heijde.D.; Braun, J.; Rudwaleit, M.; Purcaru, O.; Kavanaugh, A., 2014: Sustained Improvements in Workplace and Household Productivity and Social Participation With Certolizumab Pegol Over 96 Weeks in Patients With Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis. Value in Health 17(7): A387-A387

Laisk A.; Walker D.A., 1986: Control of phosphate turnover as a rate limiting factor and possible cause of oscillations in photosynthesis a mathematical model. A mathematical model of photosynthetic processes, comprising the primary reactions, the carbon reduction cycle, the phosphate translocator and sucrose synthesis, has been constructed and solved by computer. The aim was to simulate oscillations in...

Chilton, C., 1917: The identity of the two Amphipods, Ampelisca eschrichtii, Kroyer, and A. macrocephala, Liljeborg, considered from an antarctic point of view. Journal of Zoological Research, 2 75-93

Fahey, C.; York, R.A.; Pawlowska, T.E., 2012: Arbuscular mycorrhizal colonization of giant sequoia (Sequoiadendron giganteum) in response to restoration practices. Interactions with soil microbiota determine the success of restoring plants to their native habitats. The goal of our study was to understand the effects of restoration practices on interactions of giant sequoia Sequoiadendron giganteum with arbus...

Epifanov, N.S., 1958: Critical evaluation of the non-surgical method of treatment of perforated ulcers of the stomach and duodenum; survey of foreigh literature. Khirurgiia 34(5): 137-140

Rodi, M.S.; Garraza, L.Godoy.; Walrath, C.; Stephens, R.L.; Condron, D.Susanne.; Hicks, B.Brewer.; McKeon, R., 2012: Referral patterns for youths identified at risk for suicide by trained gatekeepers. In order to better understand the posttraining suicide prevention behavior of gatekeeper trainees, the present article examines the referral and service receipt patterns among gatekeeper-identified youths. Data for this study were drawn from 26 Ga...

Fiebinger, H., 1984: Tobacco black root rot. Symptoms in the seedbed and in the field are noted. Morphology and distribution of the causal organism, Thielaviopsis basicola, are described, with the influence of environmental factors (temp., soil pH and moisture) on its growth and spread. Cont...