+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Adjuvant corticosteroid therapy for Pneumocystis carinii pneumonia in AIDS patients

, : Adjuvant corticosteroid therapy for Pneumocystis carinii pneumonia in AIDS patients. Annals of PharmacoTherapy 26(9): 1127-1133

Obejective: To review published abstracts, case reports, and journal articles and evaluate data examining the use of systemc corticosteroids as adjuvant treatment for Pneumocystis carinii pneumonia (PCP) in patients with AIDS. Data sources: Computerized online databases, peer-reviewed journals from January 1986 through September 1991, and personal communications with a National Institutes of Health correspondent. Study selection: The authors identified 13 report pertinent to this review. By author consensus, five studies were selected from analysis based on sample size, controlled study design, and clinical outcome measures. Recommendations of an expert panel from the National Institutes of Health and the University of California also are discussed. Data extractions: Data are presented based on the methodologic strength of the studies reviewed. Studies are assessed on sample size, inclusion criteria, comparative cohort populations, specific patient outcome measures, and statistical analysis. Data synthesis: Results of the study analysis support the use of systemic corticosteroids as early adjunctive therapy for AIDS patients with moderate-to-severe PCP who have an initial arterial oxygen partial pressure of <70 mm Hg or an alveolar-arterial gradient > 35 mm Hg on room air. Improved outcomes included decreased mortality, respiratory failure, and deterioration of oxygenation. Data evaluated have shown that adjuvant corticosteriod therapy is most effective when initial within 72 hours of beginning specific antipneumocystis therapy. A small, but sometimes significant, increased rate of infection in steriod-treated patients was noted. Conclusions: Based on the literature reviewed, early systemic adjuvant corticosteroid therapy can benefit patients with moderate-to-severe AIDS-related PCP. The steroid regimen used in the largest controlled trial and recommended by the expert panel is prednisoone 40 mg bid (days 1-5), then 40 mg/l (days 6-10), then 20 mg/d (days 1-21).


PMID: 1421680

Other references

Kandasami, P.A., 1961: Inheritance of certain morphological characters in interspecific hybrids of Saccharum. Crosses of S. ojftcinarum varieties with variants of S. spontaneum showing protogyny indicated a dominant inheritance of the protogynous character. The factor in Saccharum species which determines whether the sessile or the pedicelled spikelet is...

Duffin, J., 1995: Infiltrating the curriculum: an integrative approach to history for medical students. I believe that the purpose of history in a medical school can be related to two simple goals: first, to make students a bit skeptical about everything else they are to be taught in the other lectures--skepticism fosters humility and life-long lear...

Toma, K.; Miki, D.; Kishikawa, C.; Yoshimura, N.; Miyajima, K.; Arakawa, T.; Yatsuda, H.; Mitsubayashi, K., 2016: Repetitive Immunoassay with a Surface Acoustic Wave Device and a Highly Stable Protein Monolayer for On-Site Monitoring of Airborne Dust Mite Allergens. This work describes a sensor to be incorporated into the on-site monitoring system of airborne house dust mite (HDM) allergens. A surface acoustic wave (SAW) device was combined with self-assembled monolayers of a highly stable antibody capture pr...

Rempe, E.; Mishunina, M.; Gracheva, N.; Chernaia, V., 1987: Effect of increasing levels of fertilizers on the microbial processes in soddy-podzolic heavy loam soil, nitrate content in soil and in roots of forage beets. Agrokhimiia (8) 51-57

Mitiuk, I.I.; Godlevskiĭ, A.I., 1989: Treatment of "kissing" duodenal ulcers. Sovetskaia Meditsina: 76-77

Dubucq, M.; Bouchet, M.; Gaspar, T., 1973: Peroxidase and isoperoxidase activity in sugar beet. Peroxidase and isoperoxidase activity in seedlings and stecklings of (a) tetraploid and diploid sugar beet with high sugar contents was approximately double that in (b) sugar beet with low sugar contents. 3 cathodic isoenzymes, which were present...

Lee M S.; Kwon T O., 1992: Genetic studies on wild prunus yedoensis var nudiflora and its putative parents growing in haenam districts in korea. Hortscience 27(6): 658

Michielsen, P.J.S.; Thunnissen, M.M.; Van Den Bossche, B., 2007: Clozapine and selective serotonin reuptake inhibitors: risks of toxicity. A 25-year-old woman, known to have schizoaffective disorder, presented with symptoms that had arisen a few weeks earlier. The symptoms indicated that she had a toxic clozapine blood level. The probable cause of the toxicity was a pharmacokinetic i...

Chan R.; Edward D.P.; Tso M.O.M., 1989: Immunocytochemical study of carbonic anhydrase isoenzyme c and glial fibrillary acidic protein in the preretinal membrane of retinitis pigmentosa. Investigative Ophthalmology & Visual Science 30(3 SUPPL): 306

Bogdanski, P.; Pupek Musialik, D.; Bryl, W.; Luczak, M.; Jabecka, A., 2003: Evaluation of blood pressure values in 3-month obesity treatment with use of Sibutramine. Tulunay, F C [Editor], Orme, M [Editor] European collaboration: Towards drug development and rational drug therapy : 153