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Alkaloidal content and certain pharmacological activities of fumaria parviflora lam. growing in egypt

, : Alkaloidal content and certain pharmacological activities of fumaria parviflora lam. growing in egypt. Plantes Medicinales et Phytotherapie 23(2): 109-123

No qualitative variation in the alkaloidal content of the different organs of Fumaria parviflora Lam. was observed, although they varied quantitatively when assayed by non-aqueous titration. After column chromatography of extracts, protopine and another alkaloid, suggested to be the desmethyl congener of the synthetic tetrahydroescholamine were isolated. The two alkaloids were characterized by their, chromatographic behaviour as well as UV, IR, NMR and mass spectra. Toxicological and pharmacological investigation of the ethanolic extract of F. parviflora as well as the alkaloid "protopine" isolated thereof were carried out. Both exhibited a significant decrease in intestinal muscle contractions. Significant cardioinhibitory, antiarrhythmic, hypotensive and antipyretic effects were also found. The ethanolic extract of the plant as well as protopine can, thus, be used as intestinal antispasmodic, antihypertensive and antiarrhythmic.


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