geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Arrhythmogenic effect of high blood pressure: some observations on its mechanism


, : Arrhythmogenic effect of high blood pressure: some observations on its mechanism. Cardiovascular Research 23(11): 983-992

An increase in aortic pressure is a reproducible way of causing ventricular ectopic rhythms. This study sought to determine whether it is the aortic pressure pre se or the concommitant increase in afterload or preload that has a direct arrhythmogenic effect. Experiments were carried out in 17 anaesthetised dogs. For each 10 s period the pressure and the presence of a ventricular arrhythmia (at least one ectopic beat) were noted. In nine animals an aortic valve gradient was created (and released). The results were compared to those obtained by impeding the aortic flow at the ascending aorta. The mean systolic left ventricular pressure was significantly higher in the arrhythmia associated periods in 8/9 experiments when there was an aortic valve gradient and in 5/9 experiments when there was not. In 4/9 experiments the mean aortic pressure associated with arrhythmia was significantly lower with an aortic valve gradient than when there was no gradient and no arrhythmia. In 7/9 of these experiments, coronary sinus flow was measured volumetrically during the manoeuvres applied. The coronary flow was significantly lower when there was neither arrhythmia nor aortic valve gradient than when there was an arrhythmia (with or without an aortic valve gradient). In another eight experiments a pressure reservoir in the aorta was either raised or lowered while another pressure reservoir in the left atrium was moved in the opposite direction. Thus the mean aortic pressure could be increased while the left atrial pressure was decreased and vice versa. If the left atrial pressure was taken into account, the mean difference of the aortic pressure from its expected value, derived from the aortic v left atrial pressure regression equation, was significantly higher when there was an arrhythmia than it was when there was no arrhythmia in all eight experiments. On the other hand, the mean difference in the left atrial pressure from its expected value was significantly higher when there was an arrhythmia in 1/8, lower in 2/8 and not significantly different in 5/8 experiments. It is concluded that when the blood pressure is raised, it is the increase in afterload rather than an increase in aortic pressure itself or in the preload that has an arrhythmogenic effect on the ventricles.

US$19.90

PMID: 2611806

DOI: 10.1093/cvr/23.11.983


Other references

Jaganathan, J.; Reisig, A.L.; Dugar, S.M., 1996: Analysis of cadmium in wine by ETA-AAS. American Journal of Enology & Viticulture 47(3): 355

Levesque, M.; Dinel, H.; Marcoux, R., 1980: Evaluation of the differentiation criteria for the classification of 92 peat-like materials from Quebec and Ontario. In order to evaluate the differentiation criteria for classification of organic soils, 92 peat-like materials have been characterized according to criteria generally used by the Canadian Pedological Commission (C.P.C.). The botanical composition a...

Shay, J.W.; Wright, W.E., 2007: Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies. The cell culture environment (substrate, atmosphere, and medium) can have a significant influence on the characteristics of cells that propagate from clinical samples. In this issue of Cancer Cell, Ince and colleagues report improved conditions fo...

Obel, I.W.; Cohen, E.; Millar, R.N., 1974: Chronic symptomatic sinoatrial block: a review of 34 patients and their treatment. Chest 65(4): 397-402

Sullivan, M.; Mucke, H.; Kadey, S.; Fang, C.; Williams, A., 1992: Evaluation of an indirect immunofluorescence assay for the confirmation of HIV-1 antibody in USA blood donor sera. Transfusion (Bethesda) 32(8 SUPPL ): 33S

Mitkari, B.; Nitzsche, F.; Kerkelä, E.; Kuptsova, K.; Huttunen, J.; Nystedt, J.; Korhonen, M.; Jolkkonen, J., 2014: Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery. Intravascular cell therapy is a promising approach for the treatment of stroke. However, high accumulation of cells to lungs and other filtering organs is a major concern after intravenous (i.v.) cell transplantation. This can be circumvented by i...

Dang, H-zhen.; Wei, P-kang.; Zhang, X-feng.; Liu, Z-wen., 2007: Effects of warming spleen and stomach for dispersing phlegm recipe on expression of interleukin-8 in S180 tumor tissue in mice. Objective: To observe the effects of warming spleen and stomach for dispersing phlegm recipe (Wenzhong Xiaotan Recipe, WZXTR), a compound traditional Chinese herbal medicine, on expression of interleukin-8 (IL-8) in S<sub>180</sub> tum...

Sutradhar, B.C.; Macneill, I.B., 1991: Time series valued experimental designs: A review. A review is given of the literature on time-series valued experimental designs. Most of this literature is divided into two categories depending upon the factor status of the time variable. In one category, time is an experimental factor, and in t...

Sivolap, Yu, P., 2007: The problem of psychopathology of addictive disorders. The typology of mental disturbances in addicts is presented in the article. The general standpoints on psychopathological attribution of craving are discussed. The author proposes the psychopathological independence of addictive phenomena. The pro...

Gibbons, C.P.; Read, N.W.; Trowbridge, E.A., 1986: Anal cushions. Lancet 2(8497): 42-42