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Bleomycin cisplatin as neoadjuvant chemotherapy before radical radiotherapy in localized inoperable carcinoma of the esophagus a prospective randomized multicentre study the second scandinavian trial in esophageal cancer


, : Bleomycin cisplatin as neoadjuvant chemotherapy before radical radiotherapy in localized inoperable carcinoma of the esophagus a prospective randomized multicentre study the second scandinavian trial in esophageal cancer. Radiotherapy & Oncology 24(2): 114-116

Survival and swallowing function were studied in a randomized trial of 97 patients with inoperable, localized esophageal carcinoma. Radical radiotherapy was given to 51 patients, while 46 patients had two courses of bleomycin/cisplatin before radiotherapy. The survival was 29% after one year, and 6% after 3 years in the radiotherapy group. The survival in the combined treatment group was 18 and 0%, respectively; p = 0.1895. The number of patients who could swallow any food increased from 6% before treatment to 38% after 3 months in the radiotherapy group, and from 0% to 23% in the combined group. No benefit was found by combining bleomycin/cisplatin with radiotherapy.

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PMID: 1379740


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