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Brown fat thermogenesis in ovariectomized obese rats

, : Brown fat thermogenesis in ovariectomized obese rats. Journal of Kyoto Prefectural University of Medicine 98(1): 7-12

Brown fat is now recognized to be a common effector of body temperature and energy balance regulation in rodents. To date, however, biochemical quantification of brown fat thermogenesis in ovariectomized (OVX) animals has been substantial. Therefore, we investigated brown fat thermogenesis by measuring mitochondrial guanosine-5'-diphosphate (GDP), as an indicator of thermogenic activity and oxygen consumption of interscapular brown fat in OVX and sham-operated rats. The food intake and body weight of OVX rats increased more than those of controls and OVX rats became obese. Mitochondrial GDP binding and oxygen consumption in brown fat were significantly reduced compared with those in controls. And, also, even when oVX rats were pair-fed with sham-controls, body weight in pair-fed OVX rats increased significantly more than in sham-controls. Moreover, mitochondrial GDP binding and oxygen consumption of brown fat in pair-fed OVX group were decreased significantly compared to those in sham-controls. These results suggest that reduced brown fat thermogenesis might be one of the important factors that are responsible for the development of obesity after OVX.


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