geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Chronic morphine treatment selectively suppresses macrophage colony formation in bone marrow


, : Chronic morphine treatment selectively suppresses macrophage colony formation in bone marrow. European Journal of Pharmacology 195(3): 359-364

Opioids have been shown to have diverse effects on the immune system, both in vivo and in vitro, but their interactions on immature progenitor cells have been little studied. We have examined the effects of chronic morphine treatment of mice on colony formation by bone marrow cells in vitro. Bone marrow cells from mice implanted with morphine pellets for 72 h showed a 65% decrease in their response to macrophage colony stimulating factor (M-CSF). In contrast, chronic morphine treatment had no effect on the response of bone marrow cells to granulocyte/macrophage colony stimulating factor (GM-CSF). Removal of the morphine pellets from the mice resulted in a time-dependent reversal of the inhibition of macrophage colony formation, and the inhibition was completely blocked by simultaneous administration of naloxone and morphine pellets to the mice. No inhibition of colony formation was observed in bone marrow cells from mice treated with a single acute dose of morphine. Incubation of bone marrow cells from untreated mice for 7 days with in vitro morphine concentrations as low as 25 .mu.M also reduced macrophage colony formation, and the opioid peptide .beta.-endorphin was even more potent, significantly reducing macrophage colony formation at concentrations as low as 0.25 .mu.M. In agreement with the in vivo effects, neither opioid in vitro had a significant effect on granulocyte/macrophage colony formation. These results suggest that opioids may significantly alter the maturation of immune cells, which could result in potent effects on overall immune competence.

US$19.90

PMID: 1831136

DOI: 10.1016/0014-2999(91)90476-7


Other references

Boka, J.; Mahdavi, A.H.; Samie, A.H.; Jahanian, R., 2014: Effect of different levels of black cumin (Nigella sativa L.) on performance, intestinal Escherichia coli colonization and jejunal morphology in laying hens. This study was conducted to investigate the effects of different levels of black cumin seeds (Nigella sativa L.) on performance, intestinal Escherichia coli count and morphology of jejunal epithelial cells in laying hens. A total of 100 Leghorn la...

Nirmal, S.A.; Pal, S.C.; Mandal, S.C.; Patil, A.N., 2012: Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves. Nyctanthes arbortristis Linn. (Oleaceae) is one of the well-known Indian medicinal plant. Various extracts of leaves of the plant were screened for analgesic activity by hot plate test and acetic acid-induced writhings and anti-inflammatory activi...

Sholander, J.T.; Graziani, J.A.; Schillinger, K.P.; Zachary, A.A.; Leffell, M.S., 2002: Luminex technology for tests of HLA-specific antibodies. Human Immunology 63(Supplement 1): S15

Amesz, J.; D.G.ooth, B.G., 1975: Light-induced absorbance changes due to photosystems 1 and 2 in spinach chloroplasts at minus 50 degrees C. Absorbance changes in the region 500-565 nm and at 702 nm, brought about by excitation of Photosystems 1 and 2, respectively, were measured in spinach chloroplasts at minus 50 degrees C. Either dark-adapted chloroplasts were used or chloroplasts p...

Rothenbuchner, G.; Birk, J.; Loos, U.; Raptis, S.; Fletcher, S.; Pfeiffer, E.F., 1973: Studies on 125-iodine-labeled synthetic thyrotropin-releasing hormone (TRH). Klinische Wochenschrift 51(8): 412-414

Pond, W.G.; Roberts, S.J.; Simmons, K.R., 1961: True and pseudohermaphroditism in a swine herd. Sixteen of 106 pigs from 11 litters sired by a single Yorkshire boar bred to Yorkshire sows all from the same line of breeding were diagnosed as sex intergrades as indicated by the gross external appearance of the vulva. Examination of the reprodu...

Thomas, C.L., 1968: Public health problems in the Olympic Games setting. JAMA 205(11): 754-756

Gomez, M., L.; Hurtado, C.; Dussan, J.; Parra, J., P.; Narvaez, S., 2006: Determinacion de la capacidad de degradacion de compuestos organicos persistentes por bacterias marinas aisladas de sedimentos en el caribe colombiano. 82 native marine bacterial strains capable to tolerate persistent organic compounds under aerobic conditions were isolated from sediment samples from the Colombian Caribbean. Sixty-four (64) of these bacterial strains survived in laboratory condi...

Mechanic, S.; Raynor, K.; Hill, J.E.; Cowin, P., 1991: Desmocollins form a distinct subset of the cadherin family of cell adhesion molecules. The desmosomal adhesive core is formed by four major components: desmoglein (Mr, 165,000), desmocollins I and II (Mr, 120,000 and 110,000, respectively), and a Mr 22,000 protein. Here, we report the cloning and sequencing of cDNAs encoding a bovin...

Packard, C.J.; Shepherd, J., 1982: The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery. Cholesterol excretion from the body is achieved almost exclusively via the hepatobiliary axis. Disruption of the integrity of this pathway by interruption of the enterohepatic circulation produces profound changes in cholesterol metabolism that af...