geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx


, : Clinical and histopathological considerations for the diagnosis and treatment of verrucous carcinoma of the larynx. Archives of Oto-Rhino-Laryngology 246(3): 126-132

Verrucous carcinoma of the larynx is quite distinct from well-differentiated squamous cell carcinoma and has a characteristic morphology and specific clinical behavior. It accounts for approximately 1%-2% of all laryngeal carcinomas. However, difficulties are encountered clinically in separating verrucous carcinomas from keratoses, verruca vulgaris and squamous cell carcinomas with a verrucous appearance. Between 1962 and 1982, 1504 patients with squamous cell carcinomas of the larynx were diagnosed and treated by staff physicians in the Department of Otolaryngology.sbd.Head and Neck Surgery, Washington University in St. Louis. Fifteen of these patients (1%) had verrucous carcinomas. These cases were studied in order to clarify any diagnostic problems, trace the biologic behavior of the tumors and report the results of the treatment used. Of these 15 patients, we were able to follow up 8. The latter had been treated only with surgery and none of them had received radiotherapy. One death occurred, but the patient died of other causes and remained free of cancer. Reports in the literature describe a high rate of recurrence of verrucous carcinomas following radiotherapy with occasional anaplastic transformation of tumors. No patients in our series developed a metastasis in the neck, indicating that neck dissection is not justified for patients with these neoplasms even though clinically enlarged neck nodes may be present.

US$19.90

PMID: 2757559

DOI: 10.1007/bf00456652


Other references

Pullinger, B.D., 1943: The localisation of experimental tumours in scars and healing wounds. The "Deelman phenomenon," or the localization of tumors in wounds, was repeated in 22 of 40 mice, using pure chemical carcinogenic substances. The wounds were excised within tattooed sites.

Lee, S-Jae.; Lee, S.; Lim, J.; Ahn, S-Joon.; Kim, T-Woo., 2007: Cluster analysis of tooth size in subjects with normal occlusion. Tooth-size studies are important in orthodontics. Our aim in this study was to establish normative data on tooth size with a clustering method. Dental casts of 307 subjects with normal occlusion were examined. In these subjects, the tooth-size dat...

Deshpande, V.S.; Mungle, N.P., 2009: Environment-friendly cycle time optimization and quality improvisation using Six Sigma. Healthy environment in any organization can make a difference in improving productivity and quality with low defect, lack of concentration, willingness to work, minimum accidental problems etc. Six Sigma is one of the more recent quality improveme...

Melera, P.; Peltz, R.; Davide, J.P.; O'Connell, M., 1979: Polyadenylated RNA in the lower eukaryote Physarum polycephalum. Utilizing a method which quantitatively extracts high molecular weight RNA, including intact precursor as well as mature ribosomal RNAs, adenylated molecules have been isolated from nuclear- and cytoplasmic-enriched fractions of Physarum microplas...

Garofalo, R.; Pouliart, N.; Vinci, E.; Franceschi, G.; Aldegheri, R.; Castagna, A., 2011: Anterosuperior labral tear without biceps anchor involvement: a subtle isolated cause of a painful shoulder. The purposes of this study were to determine common clinical symptoms related to an anterosuperior labral tear without biceps anchor involvement and to establish the outcome of arthroscopic management of this injury. In our database of arthroscopi...

Mcadam J.H., 1983: Factors affecting the botanical composition of hill land in northern ireland uk. Approximately 7600 ha of grassland on hill land in Northern Ireland were surveyed to quantify physical features and botanical characteristics and to investigate the factors contributing to the retention of sown species in the swards. Of the area s...

L.W.nJuan; Gong XiaoXia; Wang Hong; Zhou Su; Zhao ChunGuang; Hou TaiPing, 2005: Preliminary study of the antibiotic activities of the roots of toxin Stellera chamaejasme in the Qinghai-Tibet plateau. The antibiotic activities of the active component of Stellera chamaejasme against Escherichia coli, Staphylococcus aureus, Candida albicans, Trichophyton purpureum [T. rubrum], T. gypseum [T. mentagrophytes], Microsporum gypseum and Epidermophyton...

Zhukov, I.; Shkol'-Nikova, E.; Bagaev, V., 1975: The effect of amino salt 2,4-dichlorophenoxyacetic acid on the yield and grain quality of winter rye with different doses of fertilizers. Izvestiia 4 89-93

Goldblatt P., 1973: Proposal for the conservation of the generic name dietes against naron. Taxon 22(4): 504-505

Dobrovodsky, D., 1991: Milk bottling equipment. A small capacity milk bottling unit, designed for the sale of milk at the dairy gate, is described and its schematic diagram is given. Pasteurised milk from 25 litre containers is pumped into a distribution tank, from which one, half and quarter l...