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Comparative assessment of the release of a polyunsaturated fatty acid agent from ointments in vitro and in vivo

, : Comparative assessment of the release of a polyunsaturated fatty acid agent from ointments in vitro and in vivo. Farmatsiya (Moscow) 39(1): 18-22

Absorption of a polyunsaturated fatty acid agent form variously based ointments was comparatively studied by its pharmacological effect. An optimal ointment base was chosen for the agent from polyunsaturated fatty acids, this is polyethylene glycol-1500 and polyethylene-400 in a ratio of 1:1. A positive correlation between the results from in vitro and in vivo experiments was found, suggesting that a method for diffusing the agent to agar might be recommended to study the biopharmaceutical properties of ointments containing polyunsaturated fatty acids.


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