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Concentration of fentanyl in colostrum after an analgesic dose

, : Concentration of fentanyl in colostrum after an analgesic dose. Canadian Journal of Anaesthesia 39(3): 231-235

The purpose of this study was to measure the concentrations of fentanylin in human colostrum after intravenous administration of an analgesic dose. Thirteen healthy women were given fentanyl 2 .mu.g .cntdot. kg-1 for analgesic supplementation during either Caesarean section or postpartum tubal ligation. Serum and colostrum were collected for 45 min, two, four, six, eight, and ten hours following administration of the drug. Radioimmunoassay showed that colostrum fentanyl concentrations were greatest at 45 min, the initial sampling time, reaching 0.40 .+-. 0.59 ng .cntdot. ml-1, but were virtually undetectable ten hours later. Fentanyl concentrations were always higher in colostrum than in serum. This concluded that with these small concentrations and fentanyl's low oral bioavailability, intravenous fentanyl analegsia may be used safely in breast-feeding women.


PMID: 1551153

DOI: 10.1007/BF03008782

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