+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cortical osteofibrous dysplasia of long bone and its relationship to adamantinoma. A clinicopathologic study of 30 cases

, : Cortical osteofibrous dysplasia of long bone and its relationship to adamantinoma. A clinicopathologic study of 30 cases. American Journal of Surgical Pathology 16(3): 282-290

Thirty cases of cortical osteofibrous dysplasia (COFD) were studied in an attempt at defining the relationship of COFD to adamantinoma. The patients ranged in age from newborn to 39 years (mean 13.4 years). The male:female ratio was 1:1. Presenting symptoms were most often pain or a mass. The tibia was involved in all 30 patients; in addition, the ipsilateral fibula was involved in five patients (17%). The histologic appearance of the lesions was dominated by the combination of woven bone trabeculae with prominent osteoblastic rimming and a loose, slightly myxoid stroma (less heavily collagenized in most instances than usually encountered in intramedullary fibrous dysplasia). Results of immunohistochemical study showed isolated cytokeratin-positive cells in the stroma of 28 of the lesions (93%). However, hyperchromatic epithelial islands characteristic of adamantinoma were not found in any of the 30 cases. A control population of 50 fibro-osseous lesions (intramedullary fibrous dysplasia, sclerosing fibroxanthoma, and cranial ossifying fibroma) was studied immunohistochemically; in none of these control cases were cytokeratin-positive cells found. Follow-up data were obtained in 17 cases (57%); the period ranged from 1 to 16 years (mean 6.05 years). Certain overlapping clinical features (including the location of the vast majority of the lesions in the tibia and, less often, the fibula) and the morphologic similarities of many areas of COFD and adamantinoma (particularly the shared presence of cytokeratin-positive cells) suggest a more than coincidental association between COFD and a adamantinoma. However, to date none of the 30 cases of COFD evaluated in this study has developed an adamantinoma.


PMID: 1599019

Other references

Lovejoy, Thomas E., 1995: Will expectedly the top blow off?. Part of a special supplement on science and biodiversity policy. Biologists have a responsibility to create a sense of urgency about biological diversity, climate change, and human population growth. In recent times, trends in population growth, a...

Mallory, T.B.; Brickley, W.J., 1943: Pathology: With Special Reference To The Pulmonary Lesions. Annals of Surgery 117(6): 865-884

Ghosh, P.K.; Premchand ; Prasad, D., 1986: Biology of chickpea podborer, Heliothis armigera (Hubner). Adults of the noctuid Heliothis armigera [Helicoverpa armigera] were collected from the field in Pakistan and its biology was studied in the laboratory and is described. The effects of different foods (gram [Cicer arietinum] leaves and pods and a...

Melchert, T.E., 1968: Systematic studies in the Coreopsidinae: cyto-taxonomy of Mexican and Guatemalan Cosmos. Correlated chromosomal and morphological data are presented for 25 Mexican and Guatemalan species of Cosmos.

Golan, A.; Dishi, M.; Shalev, A.; Keidar, R.; Ginath, S.; Sagiv, R., 2011: Operative hysteroscopy to remove retained products of conception: novel treatment of an old problem. To assess the efficacy and reproductive outcome of hysteroscopic removal of retained products of conception. Retrospective analysis (Canadian Task Force classification II-3). Tertiary care university hospital. One hundred fifty-nine patients were...

Subramanian, S.; Karthik, T.; Vijayaraaghavan, N.N., 2005: Single nucleotide polymorphism for animal fibre identification. Animal fibres are highly valuable industrial products often adulterated during marketing. Currently. there is no precise method available to identify and differentiate the fibres. In this study, a PCR-RFLP technique was exploited to differentiate...

Kielbowna, Leokadia, 1963: Histological analysis of tail regeneration in Bufo bufo tadpoles. Regeneration of the epithelium, spinal cord and blood vessels of the tail occurs by direct growth of the tissue fragments. Regeneration of the notochord presents a transition to the blastematic type because the cells migrating from the fragment af...

Haywood, Jd, 1981: Discontinuous mounding as a site treatment on a flatwoods soil. Forest Service general technical report SO United States Southern Forest Experiment Station: 4) 88-91

Dornan, T.L.; Carter, R.D.; Bron, A.J.; Turner, R.C.; Mann, J.I., 1982: Low density lipoprotein cholesterol: an association with the severity of diabetic retinopathy. Diurnal profiles of total and lipoprotein cholesterol and triglycerides were measured in 11 insulin-dependent diabetic subjects without retinopathy, 10 with background and 10 with proliferative retinopathy. The groups were closely matched for age...

Morozov, NS., 1987: The Bewick's swan (Cygnus bewickii), the brent goose (Branta bernicla) and the parasitic skua (Stercorarius parasiticus) on the Piros Lake, Novgorod region. Ornitologiya, 189-190 No. 22