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Cytoplasmic receptors of steroid hormones and clinical and morphological characteristics of malignant skin melanoma


, : Cytoplasmic receptors of steroid hormones and clinical and morphological characteristics of malignant skin melanoma. Voprosy Onkologii (St Petersburg) 37(4): 441-446

Receptors of estrogens (ER), progesterone (PR), glucocorticoids (GR) and androgens (AR) were assayed in samples obtained from 142 patients with malignant melanoma. GR were observed most often (57% of cases), the precentage being significantly lower for ER (25%) and PR (18%) and extremely low for AR (4%). The occurence of GR was significantly higher in metastasis to lymph nodes (69%) and soft tissue (67%) as compared to primary tumor (39%). It was higher in acrolentiginous melanoma (83%) than in superficially extending (30%) or nodular one (33%). GR occurence rose with the increase in level of invasion (from 30% for level III to 71% for level V) and tumor thickness. In application of adjuvant chemotherapy, patients with GR-negative tumors tended to survive better than those with GR-positive tumors whereas in the chemotherapy-naive group, GR-positive tumors carried better prognosis.

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