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Differential effects of specific opioid receptor agonists on rat pup isolation cells

, : Differential effects of specific opioid receptor agonists on rat pup isolation cells. Developmental Brain Research 62(1): 17-22

The possibility was investigated that specific opioid receptor types might selectively alter the production of isolation-induced ultrasonic vocalizations. Intracisternal injections of .mu., .delta., and .kappa. opioid receptor agonists were administered to isolated 10-day-old rat pups. The .mu. receptor agonist [D-Ala2-NMe-Phe4-Gly-ol]-enkephalin (DAMGO) and .delta. receptor agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) both reduced the rate of isolation-induced ultrasonic calling in the absence of sedation. The .kappa. receptor agonist U50,488 had the opposite effect, significantly raising the rate of vocalization. Fourteen-day-old pups, with a larger .delta. receptor population, showed a greater sensitivity to DPDPE than was seen in the younger animals.


PMID: 1662121

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