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Effect of chloroquine on the sporogonic cycle of plasmodium falciparum and plasmodium berghei in anopheline mosquitoes


, : Effect of chloroquine on the sporogonic cycle of plasmodium falciparum and plasmodium berghei in anopheline mosquitoes. Acta Leidensia 57(1): 53-60

We examined the effect of chloroquine on the sporogonic development of Plasmodium falciparum NF54 (strain) and P. berghei ANKA (clone) in Anopheles stephensi and A. freeborni mosquitoes. Chloroquine (25 and 40 mg/kg body weight) was fed to mosquitoes in a blood meal at different times during the sporogonic cycle; together with the gametocyte feed, during oocyst growth, and during sporozoite migration through the hemocoel en route to the salivary glands. Regardless of the time at which the drug was administered, chloroquine had no effect on midgut infection rates, mean oocyst numbers, sporozoite infectivity, or developmental chronologies of P. falciparum or P. berghei within A. stephensi mosquitoes. There were significantly fewer P. falciparum sporozoites in the salivary glands of drug-fed vs control-fed A. stephensi mosquitoes. The dynamics of P. berghei infection in control-fed A. freeborni differed from that in A. stephensi. In A. freeborni, large numbers of oocysts (200 or more) resulted in massive numbers of sporozoite in the hemocoel by day 10 post-infection (p.i.). However, very few mosquitoes with midgut and hemocoel infections developed salivary gland infections (11 and 32% gland infection rates). In contrast, when P. berghei-infected A. freeborni were fed chloroquine on day 10 or 12 p.i., there was a marked increase in the percentage of salivary gland infections (60 and 78%), suggesting that exposure to chloroquine increased the capacity of P. berghei sporozoites to invade A. freeborni salivary glands.

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PMID: 3072820


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