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Effects of cyclosporine a and oligomycin on nonspecific permeability of the inner mitochondrial membrane

, : Effects of cyclosporine a and oligomycin on nonspecific permeability of the inner mitochondrial membrane. Biokhimiya 56(3): 529-535

The effect of oligomycin and cyclosporine A on Ca2+-induced nonspecific permeability of the inner mitochondrial membrane was under study. Both oligomycin and cyclosporine A were able to prevent the activation of nonspecific permeability; however, but cyclosporine A was the only agent which could restore the initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was not shown to be mediated through redistribution of Ca2+ ions between different subpopulations of mitochondria.


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