+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of lithium on stimulated metabolic parameters in dog thyroid slices

, : Effects of lithium on stimulated metabolic parameters in dog thyroid slices. Acta Endocrinologica 121(5): 615-620

Thyroid abnormalities may develop during chronic lithium therapy for affective disorders. Lithium, like iodide, inhibits TSH stimulation of adenylate cyclase and thyroid hormone release. The present study examined the effect of lithium on stimulation of intrathyroidal intermediary metabolism by several agonists. LiCl (5 mmol/l) did not inhibit basal cAMP, glucose oxidation or 32P incorporation into phospholipids in dog thyroid slices. Although LiCl inhibited TSH stimulation of cAMP, it did not abolish the hormone's effect on cAMP-dependent protein kinase. The stimulation of iodide organification, glucose oxidation or 32P incorporation into phospholipids by TSH, carbachol and phorbol esters was not inhibited by lithium. This is in contrast to the effects of iodide, which inhibited stimulation of glucose oxidation and 32P incorporation into phospholipids by various agonists. Thus, although both lithium and iodide inhibited TSH-stimulated cAMP formation, they act differently on intrathyroidal intermediary metabolism.


PMID: 2555992

DOI: 10.1530/acta.0.1210615

Other references

Konorev, M.R.; Litviakov, A.M.; Matveenko, M.E.; Krylov, I.V.; Kovalev, A.V.; Riashchikov, A.A., 2003: Principles of current classification of duodenitis. The paper considers the principles of classification of chronic duodenitis. The current classification of chronic duodenitis may be divided into three parts: endoscopic, histological, and etiological. The characterizing terms of the endoscopic par...

Schaefer F.; Schulte R.; Hake B.; Georgi M.; Mohr U.; Schaerer K., 1991: Validity of bioelectrical impedance analysis bia for assessment of body composition in renal transplant tx recipients. Pediatric Research 29(4 PART 2): 350A

Almendros Gonzalo; Knicker Heike; Gonzalez Vila Francisco J., 2003: Rearrangement of carbon and nitrogen forms in peat after progressive thermal oxidation as determined by solid-state (super 13) C- and (super 15) N-NMR spectroscopy. Peat samples subjected to thermal oxidation were studied by solid-state (super 13) C- and (super 15) N-NMR spectroscopy, so as to gain information on the thermal alteration of organic matter during processes such as natural fires or prescribed fir...

Marrone, F.; Mura, G., 2006: Updated status of anostraca, notostraca and spinicaudata (Crustacea, Branchiopoda) in Sicily (Italy): review and new records. A survey on distribution, phenology and status of large branchiopod crustaceans (Branchiopoda: Anostraca, Notostraca, Spinicaudata) in Sicily and in circum-Sicilian islands was carried out from autumn 2000 to winter 2004/2005 with the purpose of p...

Saini, J.S.; Sharma, A.; Grewal, S.P., 1992: Chronic corneal perforations. We report the etiological profile and management with simple patch, tarsorrhaphies, conjunctival flaps, tissue adhesive, or penetrating keratoplasty of 104 chronic corneal perforations in a North India population. Chronic corneal perforations were...

Ruelle, 1986: Resonances of chaotic dynamical systems. Physical Review Letters 56(5): 405-407

Defossez, P.; Richard, G.; Boizard, H.; O.S.llivan, M., 2002: Influence of soil water content profile on compaction. The effect of soil water content profile on soil compactibility is investigated using observations and simulations. This study follows the work of Guerif (1984) who showed that a slight drying of soil surface layer prior to wheeling prevented exce...

Lunghi, C.; Binda, P.; Morrone, M.Concetta., 2010: Touch disambiguates rivalrous perception at early stages of visual analysis. Current Biology 20(4): R143-R144

Nuorteva M.; Saari L., 1980: Larvae of acanthocinus aedilis pissodes pini and tomicus piniperda coleoptera and the foraging behavior of woodpeckers picidae. Pure cultures of 3 beetle species established under the bark of pine logs [Pinus silvestris] were exposed to predation by woodpeckers in the forest. The progeny of T. piniperda (L.) had time to emerge through the bark before the logs ware visited...

Knopf, W.; Grossmann, I.; Klages, G., 1983: Intraosseous compression osteosynthesis of the dens axis fracture--an alternative therapeutic concept?. Beitrage Zur Orthopadie und Traumatologie 30(6): 318-323