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Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat

, : Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat. European Journal of Pharmacology 199(3): 335-340

The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and brain. A concurrent decrease in platelet-free plasma 5-HT concentrations occurred after subchronic treatment. Tianeptine attenuated the large increase in 5-HT concentrations in platelet-free plasma elicited by the specific 5-HT uptake inhibitors citalopram and paroxetine. These data are compatible with the reported 5-HT uptake-enhancing activity of this antidepressant drug.


PMID: 1717295

DOI: 10.1016/0014-2999(91)90497-e

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