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Efficient calcium mobilization induced by neurokinin a in rat vas deferens


, : Efficient calcium mobilization induced by neurokinin a in rat vas deferens. European Journal of Pharmacology 204(3): 295-300

Although both neurokinin A (NKA) and norepinephrine (NE) induced similar maximal contractions in the epididymal and the prostatic site of vas deferrns, NKA affected sensitivity more potently than did NE in both sites. The NKA-induced contractions were more strongly inhibited by nicardipine, a dihydropyridine Ca2+ entry blocker, or by elimination of extracellular Ca2+ (Cao2+) in both sites. However, ryanodine, which interferes with the release onf intracellular Ca2+ (Cai2+), abolished the contractions caused by NKA in the prostatic site whereas it had no effect in the epididymal site. These results suggest that NKA-induced contraction utilizes both Cai2+ and Cao2+ in the prostatic site but mobilizes only Cao2+ in the epididymal site. Cai2+ concentration ([Ca2+]i) was measured directly with a Ca2+-sensitive fluorescent dye, fura-2. In the epididymal site NKA induced contractions with smaller increase in [Ca2+]i compared to that necessary for NE-induced contractions. These results suggest that NKA utilizes Ca2+ more efficiently than does NE and plays a role as a neuromodulator in rat vas deferens.

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