+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Electrocorticographic confirmation of focal positron emission tomographic abnormalities in children with intractable epilepsy

, : Electrocorticographic confirmation of focal positron emission tomographic abnormalities in children with intractable epilepsy. Epilepsia 31(6): 731-739

The relationship between focal disturbances of glucose utilization demonstrated by positron emission tomography (PET) and electrophysiologic abnormalities defined by intraoperative electrocorticography (ECoG) was studied in eight children (aged 13 months to 12 years) who underwent cortical resection because of intractable seizures. None of the children had pure temporal lobe epilepsy. Computed tomography (CT) and/or magnetic resonance imaging (MRI) were normal in four of the eight children. The scalp electroencephalogram (EEG) showed lateralized interictal epileptiform abnormalities in all eight and lateralized ictal onset in five of eight. In seven children, interictal PET showed focal hypometabolism; the eighth child had focal, ictal hypermetabolism. ECoG at the time of surgery showed epileptiform spiking, slowing, and/or suppression of normal background activity that in every case corresponded to the focus on PET scan. The ECoG findings support the notion that in children with epilepsy focal metabolic abnormalities on PET correspond to electrophysiologically abnormal areas of cortex, which are presumably also the epileptogenic regions. Such areas can appear normal on anatomic imaging studies (CT and MRI). When ictal scalp EEG data are ambiguous or contradictory, PET provides a less invasive means than chronic grid or depth electrode recording for evaluating whether a localized epileptogenic area exists.


PMID: 2245803

Other references

Yamazaki Toshitsugu, 2005: Geomagnetic paleointensity fluctuation revealed from marine sediment cores; a perspective as the part of the Earth system. Geomagnetic paleointensity variations can continuously be estimated using marine sediment cores having relatively uniform magnetic properties. The occurrence of large paleointensity fluctuations with periods on the order of 10 (super 3) to 10 (sup...

Koryszko, J., 1987: An observation of hymenopterous parasites hunting for larvae. Bulletin of the Amateur Entomologists' Society, 46: 130 No. 356

Mammen, A.A.; Ferrer, F.A., 2004: Nocturnal enuresis: medical management. Nocturnal enuresis is a problem that affects many children and their families. The etiology seems to be multifactorial and may include a combination of genetic factors,abnormal urodynamics, alterations in vasopressin secretion, sleep factors, psyc...

Eren, E.E.; Aykut, S.; Kayihan, A.; Aydogan, H.; Dagsali, S., 1989: Echinococcal cyst of the interventricular septum with right ventricular protrusion. Although echinococcosis (echinococcal hydatidosis) is common in sheep-raising countries such as Turkey, cardiac involvement is rare; the presence of a hydatid cyst in the interventricular septum is rarer still. We report a case of hydatid cyst of...

Bush, D.; Biswas, A.; Jones, R., 1993: Hormonal regulation of Ca2+ transport in the endomembrane system of the barley aleurone. Gibberellic acid (GA3) and abscisic acid (ABA) regulate alpha-amylase production in aleurone tissue of the barley (Hordeum vulgare L.) grain during germination. Since alpha-amylase is a Ca2+-containing protein that is synthesized on the rough endo...

Misra, S.; Rosen, T.S.; Johnson, H.L., 1999: Neurological and developmental outcomes of cocaine exposed infants followed up from 12 months to 3 years authors. Pediatrics 104(3 PART 3): 738, Sept

Reynolds, L.P.; Grazul Bilska, A.T.; Redmer, D.A., 2002: Angiogenesis in the female reproductive organs: Pathological implications. The female reproductive organs (ovary, uterus, and placenta) are some of the few adult tissues that exhibit regular intervals of rapid growth. They also are highly vascular and have high rates of blood flow. Angiogenesis, or vascular growth, is th...

Annane, D.; Chevrolet, J.C.; Chevret, S.; Raphael, J.C., 2000: Nocturnal mechanical ventilation for chronic hypoventilation in patients with neuromuscular and chest wall disorders. Chronic alveolar hypoventilation is a common complication of many neuromuscular and chest wall disorders. Long term nocturnal mechanical ventilation is used to treat an increasing number of patients. To examine the efficacy of nocturnal mechanical...

Gansheroff, L.J.; Dollard, C.; Tan, P.; Winston, F., 1995: The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo. Mutations in the SPT7 gene of Saccharomyces cerevisiae originally were identified as suppressors of Ty and delta insertion mutations in the 5' regions of the HIS4 and LYS2 genes. Other genes that have been identified in mutant hunts of this t...

Barrera M.Jr, 1988: Models of social support and life stress beyond the buffering hypothesis. Cohen, L H (Ed ) Sage Focus Editions, Vol 90 Life Events And Psychological Functioning: Theoretical And Methodological Issues 273p Sage Publications, Inc : Newbury Park, California, Usa; London, England, Uk Illus Paper 211-236