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Estimation of carbamazepine and valproic acid efficacy in alcohol post intoxication syndrome based on ethanol and acetaldehyde kinetics and biogenic monoamine content


, : Estimation of carbamazepine and valproic acid efficacy in alcohol post intoxication syndrome based on ethanol and acetaldehyde kinetics and biogenic monoamine content. Farmakologiya i Toksikologiya (Moscow) 54(5): 60-62

The effects of carbamazepine and valproic acid on disturbances of behaviour, elimination of ethanol, acetaldehyde from the blood, the contents of adrenaline, noradrenaline, dopamine, serotonin, 5-hydroxyindoleacetic acid and histamine in the brain and blood in alcoholic postintoxication syndrome were studied on male albino rats. Carbamazepine and valproic acid were shown to reduce the behavioural manifestations of the syndrome, to increase elimination of ethanol and acetaldehyde, to normalize the levels of the mediators in the brain tissues, particularly in the thalamus.

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