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Experimental induction of cardiovascular malformations in the chick embryo

, : Experimental induction of cardiovascular malformations in the chick embryo. Zeitschrift fuer Klinische Medizin (Berlin) 46(23): 1647-1653

Experimental induction of cardiovascular malformations in the chick embryo can be successfully accomplished by beta-adrenergic receptor stimulants and methylxanthines. Beta-1 receptor activity plays an important role in the teratogenic process. Isoproterenol is the most potent beta receptor stimulant and is associated with the greater teratogenic effect. Pretreatment with beta receptor blocking agents significantly reduce the incidence of malformations. Synergism of sympathomimetic agent with cocaine had been shown. Cardiovascular malformations can be related to alterations in hemodynamic function as shown by a decrease in end-diastolic and end-systolic volumes, stroke volume, and cardiac output and a rapid and sustained increase in ejection fraction. Finally, the exposure to high concentration of calcium chloride solution (100 mM) increased considerably the incidence of cardiovascular malformations.


Other references

O.R.illy S.Y.; Griffin W.L.; Jingfeng Guo, 1994: Corundum megacrysts and their genesis in Cenozoic basalts, eastern China. Pages 272-273 1994

Meggers, Betty J., 1994: Archaeological evidence for the impact of mega-Nino events on Amazonia during the past two millennia. Climatic Change 28(4): 321-338

Hughes, S.L.; Cummings, J.; Weaver, F.; Manheim, L.; Braun, B.; Conrad, K., 1992: A randomized trial of the cost effectiveness of VA hospital-based home care for the terminally ill. All admissions to a 1,100-bed Department of Veterans Affairs (VA) hospital were screened to identify 171 terminally ill patients with informal caregivers who were then randomly assigned to VA hospital-based team home care (HBHC, N = 85) or customa...

Festge O A.; Tischer W.; Rosenbaum K D.; Gross W., 1981: Urodynamic investigations volume flow and pressure flow relationships in children. Urodynamic investigations of 122 children with a normal urinary tract and of 168 children with disturbances of subvesical outflow are reported. The children were divided into 4 groups according to age and sex. Measuring methods were uroflowmetry a...

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Komarek, J., 1974: The morphology and taxonomy of crucigenioid algae (Scenedesmaceae, Chlorococcales). Archiv fur Protistenkunde: 16 (1 2) 1-75

Fowler, K.J.; Sahhar, M.A.; Tassicker, R.J., 2000: Genetic counseling for cat and dog owners and breeders--managing the emotional impact. Journal of the American Veterinary Medical Association 216(4): 498-501

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Kalpazanova, N.; Dosheva, I.; Klechkova, L., 1987: Dynamic changes in the blood glucose, glycosylated hemoglobin and glycosylated serum protein values in patients with diabetes mellitus. In 30 diabetic patients blood glucose, HbA1 and glycosylated serum proteins were studied. They were examined at the beginning of the treatment and at 7-day intervals. On the 7th day considerable changes of blood glucose level were found without re...