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Experimental studies on the therapy of japanese encephalitis virus infected rhesus monkeys by monoclonal antibodies


, : Experimental studies on the therapy of japanese encephalitis virus infected rhesus monkeys by monoclonal antibodies. Virologica Sinica 5(1): 56-62

After being infected with Japanese encephalitis virus (JEV), the rhesus monkeys appeared a series of symptoms and signs, and finally died of exhaustion of respiration and circulation. Two days after the temperature rose up to 39.degree.C, the monoclonal antibodies (McAb) were injected for therapy. The results were finer with the survival rate of 100% in different groups treated by intramuscular, intravenous, and subdural plus intramuscular injections. Among them, subdural plus intramuscular injections of the McAb was the best one. After multiple injections of the McAb, there appeared neither anaphylaxis nor delayed allergy, without obvious changes of serum IgE levels, and did not observed and damages of the main organs. The studies proved that the application of McAb from mouse safe, and it is possible and reliable for clinical usage.

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