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Extraction of fluorine 18 labelled fluoride from oxygen 18 labelled water by a fast fibrous anion exchange resin


, : Extraction of fluorine 18 labelled fluoride from oxygen 18 labelled water by a fast fibrous anion exchange resin. Applied Radiation & Isotopes 41(6): 583-586

[18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K2 CO3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [18F]fluoride as an ion pair. The resin was first dried in situ and rehydrated with [18O]H2O to avoid isotopic dilution of the target water.

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