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Fatty acid profile of plasma from aids patients and normal individuals

, : Fatty acid profile of plasma from aids patients and normal individuals. Archives of AIDS Research 3(1-3): 159-166

Essential polyunsaturated fatty acids may be the source of natural endogenous agents against HIV by preventing the spread of viral infection and by regulating immune responsiveness. Compared to controls, patients with AIDS exhibited abnormally low total plasma phospholipid and non-esterified fatty acid levels. The concentrations of C20 and C22 n-3 fatty acids were highly significantly reduced. The role of essential fatty acid metabolism and the consequence of a deficiency in n-3 fatty acids in the development of AIDS is considered. AIDS is either induced or precipitated by HIV (Gluckman et al, 1986). The mechanism by which the HIV infection is transformed progressively into a disease is not well understood in part due to the long latency period between the infection and the disease. It is possible that the disease is the result of a sequence of events that include the destruction of T helper lymphocytes by the virus, the induction of an autoimmune reaction directed at the immune system and triggered by HIV infection and the stimulation of biochemical changes induced by the virus leading to the formation of non-specific cytotoxic substances (Gluckman et al, 1986; Klatzmann and Montagnier, 1986; Klein et al, 1987). Which of these mechanisms contribute the most to the development of the disease is currently debated. In accord with these hypotheses, and in view of the long incubation period, metabolic changes could precede or parallel the pathophysiological changes associated with the different clinical stages culminating in AIDS. It seems plausible that such a correlation be based on a fundamental mechanism that progressively both provides the conditions for the replication of the virus and suppresses cellular immunity simultaneously. It is suggested that essential polyunsaturated fatty acids (EPUFA) may be the effectors of this fundamental mechanism. There are two main reasons to believe that EPUFA and/or their metabolites may play a role in controlling HIV infection and immune abnormalities associated with AIDS. First, EPUFA plays a major function in regulating immune response in vivo (Stackpoole and Mertin, 1982; Erickson, 1986; Johnston, 1985; Mertin et al, 1985; Horrobin, 1980). Second, certain EPUFA and metabolites modulate viral infectivity in vitro (Santoro et al, 1980; Giron, 1982; Kohn et al, 1980; Sands et al, 1979; Sola et al, 1986). If this hypothesis has some validity, abnormalities in the metabolism of these EPUFA should be found in patients with AIDS compared to normal individuals. The purpose of this study was to evaluate the levels of fatty acids in the plasma total lipid, phospholipid, and non-esterified fatty acid fractions from patients with AIDS and normal individuals. It would appear that patients with AIDS have highly abnormal levels of many individual fatty acids and of total phospholipid and total non-esterified fatty acids.


Other references

Feng, W.C.; Singh, A.K.; Bert, A.A.; Sanofsky, S.J.; Crowley, J.P., 1993: Perioperative paraplegia and multiorgan failure from heparin-induced thrombocytopenia. Heparin-induced thrombocytopenia and thrombosis syndrome is a rare but devastating complication. We report a patient with heparin-induced thrombocytopenia in whom heparin-induced thrombocytopenia and thrombosis syndrome developed after a cardiac o...

Baxter, R.J.; Stewart, G.R., 1990: Report of continuing field work on the desert tortoise (Gopherus agassizii) at the Twentynine Palms Marine Corps Air Ground Combat Center, spring 1985. Desert Tortoise Council Proceedings of Symposium. 1986( ); 11: 128-140

Scappaticci, A.A.; Yoo, D.C., 2012: Recurrence of lung cancer after radiofrequency ablation detected by PET/CT and contrast enhanced CT scan. Medicine and Health, Rhode Island 95(5): 146-148

Bourne, A.; Reid, D.; Hickson, F.; Torres-Rueda, S.; Weatherburn, P., 2016: Illicit drug use in sexual settings ('chemsex') and HIV/STI transmission risk behaviour among gay men in South London: findings from a qualitative study. 'Chemsex' is a colloquial term used in the UK that describes sex under the influence of psychoactive substances (typically crystal methamphetamine, mephedrone and gamma-hydroxybutyric acid (GHB)/gamma-butyrolactone (GBL)). Recently, conc...

Barone, S.R.; Mandel, F.S.; Krilov, L.R., 1994: Transmission of infectious diseases in a day care setting; effectiveness of educational intervention. Pediatric Research 35(4 PART 2): 110A

Mustonen, A-Mari.; Asikainen, J.; Aho, J.; Nieminen, P., 2007: Selective seasonal fatty acid accumulation and mobilization in the wild raccoon dog (Nyctereutes procyonoides). Previous studies on laboratory rodents, rabbits and humans have demonstrated that fatty acid (FA) mobilization from white adipose tissue (WAT) is selective and its efficiency is related to FA structure. Selective FA mobilization was also documente...

Yujra, P.R.R.; Oliveira, L.A.A. de, 1988: Water requirements of the winter maize crop in the Campos region, RJ. In trials in 1985-86, winter maize cv. Sintetico PESAGRO-RIO and Cargill 317 were grown in plots parallel to a spray line so that they received irrigation in the range 0-381 mm. In 1985 yields were highest in plots nearest the spray line but in 19...

Wu, C.K.; Santini, V.E.; Dittus, C.; Hilaire, M.H.Saint., 2016: Neuroacanthocytosis: A case with unusual clinical features & novel response to treatment. Journal of the Neurological Sciences 370: 55-56

Lu, F.; Sugano, Y.; Okabe, T.; Sato, Y., 2016: Gaze Estimation From Eye Appearance: A Head Pose-Free Method via Eye Image Synthesis. In this paper, we address the problem of free head motion in appearance-based gaze estimation. This problem remains challenging because head motion changes eye appearance significantly, and thus, training images captured for an original head pose...

Mathias, K.; Halmer, F.X., 1978: Urographic alterations after kidney stone operation. Postoperative excretory urography revealed severe complications after kidney stone removal in 17 of 102 patients. In 11 cases stone fragments or remaining stones were detected. The high frequency of prognostically important postoperative alteratio...