+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Feasibility of tomographic technetium 99m labeled hexakis 2 methoxy 2 methylpropylisonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction

, : Feasibility of tomographic technetium 99m labeled hexakis 2 methoxy 2 methylpropylisonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation 80(5): 1277-1286

99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc-Sestamibi), a new myocardial perfusion radiopharmaceutical, was injected intravenously in 11 patients within 4 hours of the onset of acute myocardial infarction before treatment with intravenous tissue-type plasminogen activator and 6-14 days later. Five patients with acute myocardial infarction who did not receive intravenous thrombolytic therapy underwent a similar injection of radiopharmaceutical. The absence of redistribution of Tc-Sestamibi permitted imaging with single-photon emission computed tomography up to 6 hours after intravenous injection to assess the distribution of myocardial perfusion at the time of administration. The region of hypoperfused myocardium on the initial images varied widely from 9% to 68% of the left ventricle and was significantly greater in anterior than in inferior infarcts (p < 0.01). The region of hypoperfused myocardium on the final images varied widely from 0% to 63% of the left ventricle and was also greater in anterior infarcts (p< 0.01). The final hypoperfused region correlated (r=-0.82) with the late resting ejection fraction and with the late regional wall motion score in the infarct segment for both anterior (r=-0.74) and inferior (r=-0.97) infarcts. There was a significant decrease (-13.+-.11%, p<0.003) in the extent of hypoperfused myocardium between the initial and final studies in the patients who received thrombolytic therapy compared with an insignifcant increase (4.+-.6%, p>0.5) in the patients who did not receive thrombolytic therapy. Tomographic imaging with Tc-Sestamibi permits determination of the amount of hypoperfused myocardium "at risk" in acute myocardial infarction. The change in myocardial perfusion determined by Tc-Sestamibi before and after therapy in acute myocardial infarction is a promising tool for assessing treatment.


Other references

Amineva, Sa, 1982: Some biological properties of diplococci isolated from swine. Biulleten' Vsesoiuznogo instituta eksperimental'noi veterinarii: 5) 79-81

Fischer, P-H.; Fischer-Piette, E., 1972: Recolte de mollusques lamellibranches sur la cote du Cambodge. Journal Conch Paris, 1101: 22-30

Mukerji, B.; Estrem, S.A.; O'Sullivan, F.X., 1994: The challenge of sensorineural hearing loss in rheumatoid arthritis. Patients with rheumatoid arthritis are exposed to a variety of pharmacologic agents capable of causing sensorineural hearing loss. We describe such a patient who was eventually found to have an acoustic neuroma. The case illustrates the difficulty...

Bajger, J., 1976: Application of venom chemistry in systematics of amphibians and reptiles. The active particles contained in venoms and toxins of amphibians and reptiles are reviewed. The considerable variety of these compounds allows their use in biochemical systematics. As examples of such attempts, the reconstruction of the history o...

Chirico, M.; Manzotti, M., 1952: Review of the concept of poikilocytosis; resistance to deformation in normal subject. Haematologica 36(9): 971-981

Livesey, G.D.vies, I., 1988: Caloric value of fibre and guar gum. Low calorie products edited by GG Birch and MG Lindley: 244

Garrachon, J.; Munoz, J.; Ortega, M., 1964: Biopsy Study Of The Capillaries Of The Skin In The Diabetic Patient. I. 1st Communication. Revista Clinica Espanola 94: 268-275

d'Errico, Francesco., 1994: Great auks of the Cosquer Cave again: a reply to McDonald. Antiquity. December; 68261: 856-858

Schinazi, R.F.; Voronkov, M.; Liotta, D.C., 1995: Potent anti-human immunodeficiency virus and hepatitis B virus activity of novel beta-L-2,3-unsaturated cytidine analogs. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 35(0): 191

Taylor, D.J.; Zimmerman, M.R.; Gardner, C.E.; Williams, J.M.; Grieser, E.A.; Tatum, J.I.; Bramoweth, A.D.; Francetich, J.M.; Ruggero, C., 2015: A pilot randomized controlled trial of the effects of cognitive-behavioral therapy for insomnia on sleep and daytime functioning in college students. The purpose of this study was to pilot test if cognitive behavioral therapy for insomnia (CBT-I) is an effective intervention for insomnia and daytime functioning in college students. College students' developmental stage and lifestyle are si...