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Forensic drug testing for opiates, III. Urinary excretion rates of morphine and codeine following codeine administration


, : Forensic drug testing for opiates, III. Urinary excretion rates of morphine and codeine following codeine administration. Journal of Analytical Toxicology 15(4): 161-166

The urinary excretion profile of free and conjugated codeine and morphine was determined by GC/MS for four healthy male subjects after intramuscular administration of 60- and 120-mg doses of codeine. Codeine and metabolites were rapidly excreted with the majority of drug appearing in the first 24 h. No dose-related differences in metabolism were observed. The initial ratio of total codeine to total morphine was substantially greater than 1.0 but declined over time. For two of the four subjects, the codeine-morphine ratio declined below 1.0 late in the elimination phase. With a 300-ng/mL cutoff, one subject tested positive on more than one occasion for total morphine and negative for codeine during the terminal elimination phase. The data indicate that urine codeine-morphine ratios are not reliable indices of the type of opiate exposure.

US$19.90

PMID: 1943064

DOI: 10.1093/jat/15.4.161


Other references

Hiraishi, H.; Ohmagari, T.; Otsuka, Y.; Yokoi, F.; Kumon, A., 1997: Purification and characterization of hepatic inorganic pyrophosphatase hydrolyzing imidodiphosphate. A 56-kDa inorganic pyrophosphatase consisting of 33-kDa subunits was purified from bovine liver almost to homogeneity. This hydrolase required divalent cations such as MgCl-2, CoCl-2, and MnCl-2 to hydrolyze PP-i and was insensitive to 2 mm sodium...

Moir, D.; Viau, A.; Chu, I.; Wehler, E.K.; Mörck, A.; Bergman, A., 1996: Tissue distribution, metabolism, and excretion of 2,4,4'-trichlorobiphenyl (CB-28) in the rat. The tissue distribution, metabolism, and excretion of 14C-labeled 2,4,4'-trichlorobiphenyl (CB-28) were studied in the rat. Following intravenous administration, radioactivity was removed from the blood rapidly and distributed to tissues. The...

Macdonald Robie; McLaughlin Fiona A., 1996: Persistent organic contaminants. Special Report - Corps of Engineers, U S

Herscovici L.; Grise G.; Thauvin C.; Lemeland J.F.; Fillastre J.P., 1988: Efficacy and safety of once daily versus intermittent dosing of tobramycin in rabbits with acute pyelonephritis. Unilateral pyelonephritis was induced in 50 rabbits by injecting Escherichia coli (minimum inhibitory concentration of tobramycin 0.25 mg/l) into the left kidney and by obstructing the ureter temporarily. Tobramycin treatment (daily dose 10 mg/kg)...

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Sanders, O.T.; Kirkpatrick, R.L., 1977: Reproductive characteristics and corticoid levels of female white footed mice fed ad libitum and restricted diets containing a poly chlorinated bi phenyl. Sixty female white-footed mice (Peromyscus leucopus) were fed either ad lib or 70% ad lib diets for 5 wk. During the last 3 wk of feeding a polychlorinated biphenyl (Aroclor 1254) was incorporated into the diets at levels of 0, 25 or 100 ppm (base...

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Dearman, R.J.; Skinner, R.A.; Deakin, N.; Shaw, D.; Kimber, I., 2004: Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay. The evaluation of allergenic potential is a key parameter in the safety assessment of novel proteins, including those expressed in genetically modified crops and foodstuffs. The majority of allergic reactions to food proteins are immediate type hy...

Huh, C.H.; Pomije, B.D.; Bolch, W.E.; Tressler, M.A.; Hintenlang, D.E., 1999: Characterization of angular dependence of p-MOSFET dosimeters for lung, soft and skeletal tissue-equivalent phantoms in the diagnostic energy range. Health Physics 76(6 SUPPL ): S111, June