+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Gonadal and adrenal effects on hepatic epidermal growth factor receptor expression in a murine model

, : Gonadal and adrenal effects on hepatic epidermal growth factor receptor expression in a murine model. Endocrinology 129(6): 3240-3246

We hypothesize that the actions of epidermal growth factor (EGF) may be modulated by changes in cell surface EGF receptor (EGF-R) expression under endocrine influences. Mouse liver cell membrane preparations were used in a RRA. During ontogenesis, both sexes showed a significant increase (P less than 0.005) in hepatic EGF-R numbers at puberty; however, males demonstrated significantly higher levels than females (P less than 0.005). Gonadectomy of adult males and females resulted in a significant (P less than 0.05) decrease and increase, respectively, in hepatic EGF-R expression. Prepubertal gonadectomy in both sexes resulted in EGF-R levels similar to those observed in adult females. Adrenalectomy of adult animals of both sexes had no effect on hepatic EGF-R numbers, but gonadectomy plus adrenalectomy virtually obliterated EGF-R expression. Short term treatment with testosterone of adult females or gonadectomized female and male mice significantly increased EGF-R numbers (P less than 0.05) to adult male levels. 17 beta-Estradiol given short term to adult males or gonadectomized male and female mice did not significantly alter EGF-R levels. EGF-R expression in androgen-insensitive male mice was significantly reduced (P less than 0.005) to female levels. We conclude that 1) hepatic EGF-R numbers increase post-pubertally in both sexes; 2) hepatic EGF-R expression is significantly stimulated by testosterone, and this effect depends on a functional androgen receptor; 3) the ovary has an inhibitory effect on adult hepatic EGF-R numbers; however, this effect does not appear to be mediated by estrogens; and 4) the adrenal gland has a stimulatory effect on adult hepatic EGF-R expression.


PMID: 1954902

DOI: 10.1210/endo-129-6-3240

Other references

Lhbelt, W., 1971: Fertilizing on chemically treated areas. The application of 20 t/ha dung and 200 kg of 20: 20 fertilizer in the 1st year, 600 kg complete fertilizer that contains Mg and trace elements or 350 kg N + Mg ("Stickstoffmagnesia") and 460 kg 18: 25 fertilizer in the 2nd year, 20 m3 l...

Manley, B.; Goulding-Cj; Lawrence, M., 1987: Stand assessment by log grades using MARVL. FRI bulletin Forest Research Institute New Zealand Forest Service: (132)

Gurvitch, A.M., 1964: The Significance Of N. Amygdalae In The Genesis Of Electrical Activity Of The Brain During Recovery After Prolonged Circulatory Arrest. Electroencephalography and Clinical Neurophysiology 16: 549-560

Scabardi, M.; Ronco, C.; Chiaramonte, S.; Feriani, M.; Agostini, F.; L.G.eca, G., 1992: Dynamic catheterography in the early diagnosis of peritoneal catheter malfunction. The dynamic catheterography is an image technique that allows to study the peritoneal solution inflow and outflow phases in case of catheter malfunction. The examination is carried out in three subsequent steps: 1) direct examination without contr...

Larson J.D.; Schulz A.R., 1973: Bovine thyroid glutamate dehydrogenase. Proceedings of the Indiana Academy of Science 82: 129

Kalluri, H.S.G.; Ticku, M.K., 1999: Potential involvement of tyrosine kinase pathway in the antagonist induced upregulation of the NMDA receptor NR2B subunit in cortical neurons. The aim of this study was to study the potential mechanism(s) involved in the antagonist induced upregulation of the N-methyl-d-aspartate receptor (NMDA) NR2B subunit. The results show that chronic treatment of cortical neurons with tyrosine kinas...

Van, D., B., H.; Van, W., G.M.T.; Kumar, R.; Hostetler, K.Y., 1998: Synthesis of liponucleotides. Official Gazette of the United States Patent & Trademark Office Patents 1212(2): 1878, July 14

Goulet, T.L.berman.; Coffroth,, 1997: A within colony comparison of zooxanthella genotypes in the Caribbean gorgonian Plexaura kuna. Unknown

English, N.J.; Mooney, D.A., 2007: Denaturation of hen egg white lysozyme in electromagnetic fields: a molecular dynamics study. Nonequilibrium molecular dynamics simulations of hen egg white lysozyme have been performed in the canonical ensemble at 298 K in the presence of external electromagnetic fields of varying intensity in the microwave to far-infrared frequency range...

Kacir, K.S., 1992: Attitudes of certified registered nurse anesthetists toward AIDS and AIDS patients. This study was intended to examine and identify the nature of CRNAs' attitudes concerning acquired immune deficiency syndrome (AIDS) and patients with homosexual lifestyles. This research question has been previously addressed using sample po...