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Gonadotropin and gonadosteroid response to dexamethasone in male depressive patients and normal controls


, : Gonadotropin and gonadosteroid response to dexamethasone in male depressive patients and normal controls. European Journal of Psychiatry 4(1): 45-52

According to previous studies dexamethasone does not only exert an influence on the activity of the hypothalamo-pituitary-adrenal axis but also on other endocrine systems. A study on six male depressive patients before and after recovery and 20 male healthy controls revealed an increase, especially in testosterone and LH, afer dexamethasone administration during depressive illness. A comparable effect of dexamethasone was no longer present after recovery and in normal controls. These results point to an abnormal response of the hypothalamo-pituitary-gonadal axis to dexamthasone during depression which might be related to alterations of glucocorticoid receptor density and dexamethasone pharmacokinetics.

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