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Gonadotropin releasing hormone loading test with bromocriptine treatment new possibility in differential diagnostic of normoprolactinemic anovulation


, : Gonadotropin releasing hormone loading test with bromocriptine treatment new possibility in differential diagnostic of normoprolactinemic anovulation. Orvosi Hetilap 133(28): 1745-1749

An anovulation group with normal basal prolactin level (<600 mU/l) was found during GnRH loading tests. After GnRH administration there was a definite increase in prolactin value together with an insufficient hypophyseal response. Bromocryptine treatment was commenced on the 10th day (daily 2.5 mg) before carrying out the GnRH loading tests again. During the repeated tests prolactin levels remained normal, basal FSH and LH values increased and reactive hypophyseal responses occurred. On the basis of the examination a group ("latens hyperprolactinemia") responding with increased prolactin production during GnRH administration was found. This higher prolactin level inhibits gonadotropin release from hypophysis. In these cases ovulation induction with bromocryptine is adviseable in spite of basal prolactin level is normal.

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