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Grafting of fetal pancreata into neonatal rat brain


, : Grafting of fetal pancreata into neonatal rat brain. Transplantation 49(5): 857-861

Undigested fetal pancreatic tissue has been previously shown to have immunogenic properties, even after transplantation into the adult rat brain, a relatively immunoprivileged site. In the present study, iso-, allo-, and xenografts of fetal pancreas were placed into neonatal rat brain parenchyma and ventricles in order to determine the extent and quality of its survival in this environment. Adult recipients of the same tissue types were used as controls. Selective survival of insulin-staining beta cells was observed in neonates (n = 33) over the 6-week period of the experiment. Ducts and acini were gradually destroyed in allo- and xenografts, disappearing completely by the 42nd day, while there were no such changes in the isografts. The absence of an acute inflammatory reaction was noted, but there were varying degrees of lymphocytic infiltration, though small (20 .+-. 4 lymphocytes per average graft area of 0.16 mm2) in all but one graft. This infiltrate was greatest in allografts, with a significant increase observed after 14 days, corresponding to the time when the ducts started to disappear. Other structures present included fibroblasts and blood vessels. The latter increased significantly with time after transplantation. Unlike isografts placed in the parencyma of adult rats, allo- and xenografts were rejected from the earliest time observed, 7 days postoperatively. In summary, these data show that beta cells in rat fetal pancreas will survive when grafted across major allogeneic and xenogeneic barriers for up to 6 weeks, without utilization of any form of immunosuppression, provided the recipients are neonates.

US$19.90

PMID: 2336701

DOI: 10.1097/00007890-199005000-00003


Other references

Cremer, N.E.; Johnson, K.P.; Fein, G.; Likosky, W.H., 1979: Cytotoxic antibody to cells infected with measles virus in serum and cerebrospinal fluid of multiple sclerosis and control patients. Sera and cerebrospinal fluids (CSFs) from 66 patients selected from a larger sample of multiple sclerosis (MS) and control patients were studied for presence of complement-dependent cytotoxic (CT) antibody against baby hamster kidney cells infecte...

Koehler, P.; Fischer, H.; Schmitt, J., 2010: Atmospheric delta13 CO2 and its relation to pCO2 and deep ocean delta13 C during the late Pleistocene. The ratio of the stable carbon isotopes of atmospheric CO2 (delta13 CO2 ) contains valuable information on the processes which are operating on the global carbon cycle. However, current delta13 CO2 ice core records are still limited in both resolu...

Kim, H., 1989: Multi-unit providers survey. Psychiatric expansion slows as focus shifts. Modern Healthcare 19(22): 56-8, 60, 62-3

Leblanc, A.; Labayle, D., 1988: Digestive hemorrhages of Turner's syndrome. A case. Presse Medicale 17(4): 164-164

D'souza, N.; Swami, M.; Bhagwat, S., 2011: Comparative study of dexamethasone and ondansetron for prophylaxis of postoperative nausea and vomiting in laparoscopic gynecologic surgery. To compare intravenous dexamethasone and ondansetron for the prophylaxis of postoperative nausea and vomiting (PONV), a main complaint that affects almost 40%-75% of patients undergoing laparoscopic gynecologic surgery. In a prospective study, 93...

Anonymous, 1965: Training of psychiatric nurses. Tijdschrift Voor Ziekenverpleging 18(22): 821-823

Sahgal, A.; Keith, A.B., 1986: Locomotor activity and neurotensin: resolution of discrepancies in effects?. Psychopharmacology 88(1): 131-132

Shinohara, M., 1989: Study on the steroid sulfatase (STS) activity in normal individuals and patients with abnormal sexual differentiation. The STS (steoid sulfatase) gene which has been assigned to the short arm of human X chromsomes (band p22) is thought to have escaped from Lyon's inactivation. For that reason, the STS enzyme activities differ between male and female according...

Czaja, A., 1982: Courtship patterns of Urodela. Przeglad Zoologiczny, 262: 161-170

Alessandri, J-Luc.; Cuillier, F.; Ramful, D.; Ernould, S.; Robin, Séphanie.; de Napoli-Cocci, S.; Rivière, J-Pierre.; Rossignol, S., 2008: Perlman syndrome: report, prenatal findings and review. Perlman syndrome is a rare overgrowth syndrome characterized by polyhydramnios with neonatal macrosomia, nephromegaly, distinctive facial appearance, renal dysplasia, nephro-blastomatosis, and predisposition to Wilms tumor (WT). We report on a new...