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Granular cell brain tumors of the laboratory rat: an immunohistochemical approach

, : Granular cell brain tumors of the laboratory rat: an immunohistochemical approach. Acta Neuropathologica 82(2): 112-117

We have studied paraffin-embedded specimens of 17 rat granular cell brain tumors (GCBT) from four long-term drug safety carcinogenicity studies by peroxidase-antiperoxidase (PAP) immunohistochemistry with either polyvalent or monoclonal antibodies against glial fibrillary acidic protein (GFAP), S-100 protein (S-100), Leu-7 epitopes, vimentin (VIM), keratin, desmin, and myelin basic protein. We have found that 9 of the 17 GCBT contained GFAP-positive, S-100-positive, and VIM-positive astrocytes, while GFAP-positive and VIM-positive granular cells were observed in 5 of these 9 tumors. Our findings indicate that astroglial cells are involved in rat GCBT and suggest that an astrocytic origin should be considered for these neoplasms.


PMID: 1718127

DOI: 10.1007/bf00293953

Other references

Kim, J.G.k; Ha, S.W.o; Kim, B.W.n, 1998: Oxygen free radical induced impairment of endothelium dependent relaxation in diabetic rat aortas. Shinn, S H [Editor], Shichiri, M [Editor], Kim, K -W [Editor] International Congress Series; Recent advances on the pathogenesis and management of diabetes mellitus 210-214

Didmanidze, EA., 1980: Materials on the fauna of Macrolepidoptera of Tusheti.. Vestnik Gosudarstvennogo Muzeya Gruzii, 30: 126-166 A

Rajagopalan, M.; Oh, I-Kwon., 2011: Fullerenol-based electroactive artificial muscles utilizing biocompatible polyetherimide. Two essential functional requirements for electroactive artificial muscles, which can be used for biomedical active devices, are biocompatibility and sufficient range of motion. Fullerenol nanoparticles and their derivatives have been validated as...

Takeuchi S.; Sakura Y.; Suzuki A.; Ikeda T., 2001: Observation of suspended sediment during rain events in the valley-head area of the Simosa Upland, Chiba Prefecture. Chikei = Transactions Japanese Geomorphological Union: , Pages 236. 2001.

Reik, M.; Germann, G.; Sauerbier, M.; Müller, M., 2009: New bone-ligament-bone transplant from plantar plates of the toes and possible use in reconstruction of the scapholunate ligament. An anatomical study. Various treatment options have been proposed for reconstruction of the scapholunate ligament. However, none of these methods prevent patients with scapholunate instability from developing wrist arthritis. This study was performed to investigate a...

Svitil, J., 1981: Chemization of plant production and the protection of water wells from pollution. Agrochemia 1(6): 161-163

Rostila, M.; Saarela, J.; Kawachi, I., 2013: Fatal stroke after the death of a sibling: a nationwide follow-up study from Sweden. Although less studied than other types of familial losses, the loss of a sibling could be a potential trigger of stroke as it represents a stressful life event. We studied the association between loss of a sibling and fatal stroke up to 18 years s...

Bowers, B., 1993: Qualitative research in nursing. 4. Qualitative research in nursing: reflections on the state of the art. Kango Kenkyu. Japanese Journal of Nursing Research 26(4): 347-360

Magnasco, A.; Alloatti, S.; Coppello, F.; Solari, P., 1999: A new simple screening test of recirculation based on glucose infusion compared to urea test. Nephrology Dialysis Transplantation 14(9): A186, Sept

Birnbaum, D.; Sommers, M.J., 1989: Actor/task incongruity and nurses' work attitudes. Journal of Health and Human Resources Administration 10(4): 351-360