+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Granulocyte macrophage colony stimulating factor gm csf in emergency treatment

, : Granulocyte macrophage colony stimulating factor gm csf in emergency treatment. Schweizerische Medizinische Wochenschrift 121(12): 413-417

Granulocyte-macrophage colony stimulating factor (GM-CSF) has been tested for tolerability and efficacy on a compassionate need case basis in 17 patients (5 females, 12 males aged 4-72 yearsm median 35 years). GM-CSF was given at the rate of 3.5-32 .mu.g/kg for 2-64 days as a continuous infusion for the following indications: impending rejection following bone marrow transplantation (5 patients), severe neutropenia secondary to chemotherapy in tumor patients (5), severe aplastic anemia (3), immune granulocytopenia (2) and accidental overdose with cytostatic agents (2 patients). Tolerance of GM-CSF was good in regard to doses of up to 16 .mu.g/kg. Fever, myalgia and eosinophilia were the most frequent side effects. The patient treated with 32 .mu.g/kg developed thrombosis of the vena cava. Efficacy is more difficult to assess in this heterogeneous population, but 11 of 17 patients showed increased granulocyte counts and 3 patients clearly recovered from severe neutropenia. The role of GM-CSF in this recovery, however, cannot be proven. The results further indicate that GM-CSF cannot reverse ongoing rejection following allogenic BMT and cannot correct immune neutropenia. The value of GM-CSF therapy in patients with severe aplastic anemia and in the context of chemotherapy still needs to be defined. It is certainly indicated in patients with an accidental overdose of chemotherapeutic agents.


Other references

Hartmann, E.C.; Boettcher, M.I.; Bolt, H.M.; Drexler, H.; Angerer, Jürgen., 2008: N-Acetyl-S-(1-carbamoyl-2-hydroxy-ethyl)-L-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: comparison with the simultaneously excreted other mercaptuic acids. The N-acetyl-S-(1-carbamoyl-2-hydroxy-ethyl)-L: -cysteine (iso-GAMA) could be identified as a further human metabolite of acrylamide. In this study, we report the excretion of d(3)-iso-GAMA in human urine after single oral administration of deuter...

Anonymous, 2014: Prescribing and dispensing. Journal of the California Dental Association 42(1): 60-62

Schmidt, G.A., 1988: The Florida story on long term care trends. Provider 14(11): 21-23

Tompkins R.; Krotoski Gwozdziowski D., 1983: Mutants cell markers and inbred lines of xenopus laevis for developmental studies. Genetics 104(1 PART 2): S69

Kalloo, G., 1998: Vegetable research in India. Vegetable production in India is described, including genetic improvement and cultivar development, the development of off-season cultivars to enable year-round production, crop management, pest and disease control and seed production. Lists of op...

Shen, X.; Hu, G-Bin.; Jiang, S-Jing.; He, F-Rong.; Xing, W.; Li, L.; Yang, J.; Zhu, H-Fen.; Lei, P.; Shen, G-Xin., 2010: Engineering and characterization of a baculovirus-expressed mouse/human chimeric antibody against transferrin receptor. Transferrin receptor (TfR) has been explored as a target for antibody-based therapy of cancer. In the previous study, we reported a murine anti-TfR monoclonal antibody (mAb) 7579 had good anti-tumor activities in vitro. In an attempt to reduce its...

Pieron, Henri., 1910: Le rythme des attitudes mimetiques chez un Phasmide (Orthopteres). Le Dixippus morosus. Bulletin du Museum Paris, 193-196

Gerard, A.; Gouvitsos, F.; Boufflers, E., 1997: Interest of the COPA versus facial mask in emergency procedures. Anesthesiology (Hagerstown) 87(3 SUPPL ): A992

Kellgren, J.H., 1977: Pain in the rheumatic diseases. Reports on Rheumatic Diseases: 1-2

Weigle, W.O.; Chiller, J.M.; Habicht, G.S., 1972: Effect of immunological unresponsiveness on different cell populations. Transplantation Reviews 8: 3-25