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Granulocyte metabolic activity in patients with chronic nonspecific lung diseases

, : Granulocyte metabolic activity in patients with chronic nonspecific lung diseases. Terapevticheskii Arkhiv 63(11): 85-87

Biochemiluminescent (BCL) investigation of oxidative metabolism in patients suffering from chronic nonspecific lung diseases (CNLD) has shown activation of granulocyte metabolism measured by zymosan-dependent luminol-amplified chemiluminescence and the intensification of lipid peroxidation estimated by spontaneous serum BCL. At the same time H2O2-induced BCL was decreased, attesting to the abatement of antioxidative activity. The revealed imbalance of oxidative and antioxidative processes may be the pathogenic factor in CNLD development.


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