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Herpesviruses immune escape artists?

, : Herpesviruses immune escape artists?. Clinical Infectious Diseases 14(4): 933-941

Viral persistence depends on the successful avoidance of the host's immunologic surveillance system. This review, which focuses specifically on the herpesviruses, delineates several possible strategies for evading or delaying the immune response. One strategy common to all herpesviruses is the establishment of latency, a state in which the virus may be partially or even completely hidden from the immune system. Other proposed mechanisms of immune evasion include interaction of the virus with components of the humoral immune system, virus-induced modulation of cell-surface recognition structures, and virally mediated interferences in antigen processing. Additional strategies include molecular mimicry and the ability of one particular herpesvirus to encode an immunosuppressive cytokine. Although a detailed understanding of the molecular mechanisms of herpesvirus-mediated immune evasion is currently lacking, future studies should identify those critical interactions between host and virus that may prove amenable to therapeutic intervention.


PMID: 1315587

DOI: 10.2307/4456433

Other references

Straub, C.; Sabatini, B.L., 2014: How to grow a synapse. Activity-dependent alterations in the strength of an individual glutamatergic synapse are often accompanied by changes in the size and shape of the postsynaptic terminal. Two studies in this issue of Neuron, Meyer et al. (2014) and Bosch et al....

Nowe P., 1969: Pseudostenosis of the pyelo ureteral juncture. Journal Belge De Radiologie: 277-278

Mounier-Kuhn, P.; Morgon, A., 1967: Indemnity in occupational deafness. Journal de Medecine de Lyon 48(131): 1691-1696

Little, M., 1991: When do you 'say no' to work assignments?. Tennessee Nurse 54(3): 17-19

Robinson, A.E., 1967: Critical survey of barbiturate and allied poisoning. Medicine, Science, and the Law 7(1): 17-22

Williams, K.W.; Smith, R.C., 1975: Recent advances in column chromatography. Progress in Medicinal Chemistry 12: 105-158

Anonymous, 2008: Two treatments for heart attack. Angioplasty or clot-busting drugs: who benefits from which therapy? Time is of the essence in both. Dukemedicine Healthnews 13(10): 1, 11-1, 11

Emmet, AM., 1986: The early instars of the larva of Euproctis similis (Fuessly) (Lep.: Lymantriidae). Entomologist's Record and Journal of Variation, 985-6: 97

Kurtz C., 1991: The evolution of information gathering operational constraints. Meyer, J -A And S W Wilson (Ed ) From Animals to Animats; First International Conference on Simulation Of Adaptive Behavior, Paris, France, September 24-28, 1990 X+551p Mit Press: Cambridge, Massachusetts, Usa; London, England, Uk Illus Maps Paper 376-381

Narizuka, A.; Tachikawa, Y.; Kanai, H.; Sakurai, H., 1990: Characteristic and cultivation method of Asanohikari decided for the new recommended rice variety. Asanohikari, a new variety resistant to rice stripe disease [rice stripe tenuivirus] and blast [Pyricularia oryzae], was recommended for cultivation in Gunma prefecture in 1989. It is high yielding (53.2-57.5 kg/a), producing grains with good eati...