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Hiv antibodies in pediatric hemophiliacs in nagasaki japan


, : Hiv antibodies in pediatric hemophiliacs in nagasaki japan. Acta Medica Nagasakiensia 34(1): 47-52

Human immunodeficiency virus (HIV) antibodies were assayed in 34 pediatric patients (28 patients with hemophilia A, 3 hemophilia B, and 3 von Willebrand's disease) of Nagasaki Prefecture. Thirteen of hemophilia A patients were positive (46.4%), 2 of hemophilia B patients were positive (66.7%) and 1 of von Willebrand's disease patients was positive (33.3%). Seropositive patients totaled 16 out of 34 and sero-positive rate was 47.1%. In Nagasaki University Hospital, HIV-antibodies were detected in 6 of 9 hemophilia A patients, but none in hemophilia and von Willebrand's disease patients. When compared with sero-negative patients, sero-positive patients had a depressed helper/suppressor T (OKT4/T8) ratio and a relative increase in serum IgG levels (p < 0.05). Absolute lymphocyte counts in sero-positive patients did not differ from sero-negative patients. The reverse transcriptase activities were detected in the peripheral mononuclear cell cultures in 3 of 4 sero-positive hemophilia A patients from Nagasaki University Hospital by Dri J. A. Levy in 1985. The above results suggest that exposure to HIV is widespread in asymptomatic hemophiliacs. Hence, further studies for preventive measures and therapy of Acquired Immunodeficiency Syndrome (AIDS) must be implemented.

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