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Increased serotonin 2 5 ht 2 receptor binding as measured by tritiated lysergic acid diethylamide tritiated lsd in the blood platelets of depressed patients

, : Increased serotonin 2 5 ht 2 receptor binding as measured by tritiated lysergic acid diethylamide tritiated lsd in the blood platelets of depressed patients. Life Sciences 44(11): 725-734

3H-Lysergic acid diethylamide (3H-LSD) binding, a putative measure of 5-HT2 receptor binding, was studied in the blood platelets of 29 depressed patients and 24 normal controls. The Bmax (maximum number of 3H-LSD binding sites) in the blood platelets of depressed patients was significantly greater than that of normal volunteers. This increase in Bmax was due to an increase in female depressed patients only. Bmax was significantly lower in female compared to male normal controls but there was no difference between male and female depressed patients. There was also no difference in Kd (an inverse measure of affinity of 3H-LSD binding to its sites) between normal controls and depressed patients. The correlations between Bmax of 3H-LSD binding and the Bmax of the 3H-imipramine binding site or the Vmax of 5-HT uptake sites were not significant. The role of serotonergic processes in the psychobiology of depression is discussed.


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Koletzko, B.; Kupke, I.; Wendel, U., 1992: Treatment of hypercholesterolemia in children and adolescents. In patients with severe genetic hypercholesterolemia, therapeutic reduction of elevated serum total cholesterol and LDL cholesterol should begin in early childhood to lower the risks of cardiovascular disease later in life. We evaluated the effect...

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Kojima, Y.; Tozawa, K.; Kawai, N.; Sasaki, S.; Hayashi, Y.; Kohri, K., 2006: Long-term outcome of upper urinary tract carcinoma in situ: effectiveness of nephroureterectomy versus bacillus Calmette-Guérin therapy. We examined the long-term outcome and compared the usefulness of nephroureterectomy with that of bacillus Calmette-Guérin (BCG) therapy for the management of upper urinary tract carcinoma in situ (CIS). We retrospectively reviewed the post-treatm...

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Rahim S.G.; Selway J.W.T., 1989: 2 deoxy 5 ethynyluridine 3 5 diesters for treatment of vzv and cmv infections us patent 4863906 september 5 1989. Official Gazette of the United States Patent & Trademark Office Patents 1106(1): 472

Rahman, N.; Douglas, J.; Hanks, S.; Temple, I.K.; Hughes, H.E.; Cole, T.; Childhood Overgrowth Consortium, 2002: Intragenic mutations of NSD1 are a major cause of Sotos syndrome and Weaver syndrome but do not account for other overgrowth phenotypes. American Journal of Human Genetics 71(4 Supplement): 169, October