geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Increased serotonin 2 5 ht 2 receptor binding as measured by tritiated lysergic acid diethylamide tritiated lsd in the blood platelets of depressed patients


, : Increased serotonin 2 5 ht 2 receptor binding as measured by tritiated lysergic acid diethylamide tritiated lsd in the blood platelets of depressed patients. Life Sciences 44(11): 725-734

3H-Lysergic acid diethylamide (3H-LSD) binding, a putative measure of 5-HT2 receptor binding, was studied in the blood platelets of 29 depressed patients and 24 normal controls. The Bmax (maximum number of 3H-LSD binding sites) in the blood platelets of depressed patients was significantly greater than that of normal volunteers. This increase in Bmax was due to an increase in female depressed patients only. Bmax was significantly lower in female compared to male normal controls but there was no difference between male and female depressed patients. There was also no difference in Kd (an inverse measure of affinity of 3H-LSD binding to its sites) between normal controls and depressed patients. The correlations between Bmax of 3H-LSD binding and the Bmax of the 3H-imipramine binding site or the Vmax of 5-HT uptake sites were not significant. The role of serotonergic processes in the psychobiology of depression is discussed.

US$29.90


Other references

Koletzko, B.; Kupke, I.; Wendel, U., 1992: Treatment of hypercholesterolemia in children and adolescents. In patients with severe genetic hypercholesterolemia, therapeutic reduction of elevated serum total cholesterol and LDL cholesterol should begin in early childhood to lower the risks of cardiovascular disease later in life. We evaluated the effect...

Takahashi Jun ichi; Yagi T., 1936: Resource rocks of the E. Tsugaru oil field. Japanese Assoc Mineralogists

Watson, V.H.; Burson, B.L., 1985: Bahiagrass, carpetgrass and dallisgrass. Distribution, adaptation, morphology, importance, use, cv., management, seed production, diseases and pests of Bahia grass (Paspalum notatum), carpet grass (Axonopus affinis) and Dallis grass (P. dilatatum) in the USA are discussed.

de Sequera, P.; Corchete, E.; Bohorquez, L.; Albalate, M.; Perez-Garcia, R.; Alique, M.; Marques, Mía.; García-Menéndez, E.; Portolés, Jé.; Ramirez, R., 2017: Residual Renal Function in Hemodialysis and Inflammation. Residual renal function (RRF) has an important effect on uremic toxin clearance, on volume control, on quality of life, and on mortality. In patients with chronic kidney disease (CKD), microinflammation with an increased percentage of CD14<sup&...

Bora, M.Kumar., 2013: Internal Jugular Phlebectasia: Diagnosis by Ultrasonography, Doppler and Contrast CT. Jugular phlebectasia is an isolated saccular or fusiform dilation of a vein without tortuosity. Its aetiology remains controversial. It is infradiagnosed, as it is generally asymptomatic. However, it has been increasingly recognized in recent year...

Eagle, D., 2012: Commentary: can you replace something with nothing?. Journal of Oncology Practice 7(5): 293-295

Kojima, Y.; Tozawa, K.; Kawai, N.; Sasaki, S.; Hayashi, Y.; Kohri, K., 2006: Long-term outcome of upper urinary tract carcinoma in situ: effectiveness of nephroureterectomy versus bacillus Calmette-Guérin therapy. We examined the long-term outcome and compared the usefulness of nephroureterectomy with that of bacillus Calmette-Guérin (BCG) therapy for the management of upper urinary tract carcinoma in situ (CIS). We retrospectively reviewed the post-treatm...

van Dijk, N.; Fletcher, S.; Madden, C.E.; Marken, F., 2002: Nanocomposite electrodes made of carbon nanofibers and black wax. Anodic stripping voltammetry of zinc and lead. Nanocomposite electrodes offer exciting new possibilities in electroanalytical chemistry. In this preliminary study, nanocomposite electrodes made of carbon nanofibers and black wax were characterized and investigated as novel substrates for metal...

Rahim S.G.; Selway J.W.T., 1989: 2 deoxy 5 ethynyluridine 3 5 diesters for treatment of vzv and cmv infections us patent 4863906 september 5 1989. Official Gazette of the United States Patent & Trademark Office Patents 1106(1): 472

Rahman, N.; Douglas, J.; Hanks, S.; Temple, I.K.; Hughes, H.E.; Cole, T.; Childhood Overgrowth Consortium, 2002: Intragenic mutations of NSD1 are a major cause of Sotos syndrome and Weaver syndrome but do not account for other overgrowth phenotypes. American Journal of Human Genetics 71(4 Supplement): 169, October