geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease


, : Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Annals of Neurology 32(3): 371-375

A higher prevalence of dementia in individuals with fewer years of education has suggested that education may protect against Alzheimer's disease (AD). We tested whether individuals with more years of education have a more advanced AD before it is clinically evident. As a measure of pathophysiological severity, we quantified regional cerebral blood flow (rCBF), by the 133Xenon inhalation techniques; a specific pattern of flow reduction in the parietotemporal cortex corresponds to AD pathology. In 3 groups of patients with probable AD, matched for clinical measures of dementia severity but with varying levels of education, whole-cortex mean flows were comparable. However, the parietotemporal perfusion deficit was significantly greater in the group with the highest level of education, indicating that AD was more advanced in this group. We conclude that education or its covariates or both may provide a reserve that compensates for the neuropathological changes of AD and delays the onset of its clinical manifestations.

US$19.90

PMID: 1416806

DOI: 10.1002/ana.410320311


Other references

Lecompte, T.; Hardy, J-François., 2006: Antiplatelet agents and perioperative bleeding. Purpose: To briefly review the risks, in patients presenting for surgery, associated with the available antiplatelet agents, and to present the principles that should guide the evaluation of these risks and how to manage them.Methods: A narrative...

Wang, H.; Chen, L.; Zhang, L.; Gao, X.; Wang, Y.; Weiwei, T., 2016: Protective effect of Sophoraflavanone G on streptozotocin (STZ)-induced inflammation in diabetic rats. NlmCategory="UNASSIGNED">The present study was designed to investigate the protective effect of Sophoraflavanone G (SG) on streptozotocin (STZ)-induced diabetic rats. The rats were intraperitoneally injected with STZ (35mg/kg). 7days...

Rachel, R.; Meyer, C.; Klingl, A.; Gürster, S.; Heimerl, T.; Wasserburger, N.; Burghardt, T.; Küper, U.; Bellack, A.; Schopf, S.; Wirth, R.; Huber, H.; Wanner, G., 2011: Analysis of the ultrastructure of archaea by electron microscopy. The ultrastructural characterization of archaeal cells is done with both types of electron microscopy, transmission electron microscopy, and scanning electron microscopy. Depending on the scientific question, different preparation methods have to...

Nayar, M.P., 1974: Neodriessenia new genus of melastomataceae. NEODRIESSENIA, a new genus of Melastomataceae endemic to the Island of Borneo, is described here. Neodriessenia is allied to Driessenia Korth., but differs in having stamens with conspicuously produced connective which are dorsally spurred and ven...

Gaynor, S.E.; Creamer, J.L.; Reschak, G.L.; Clayton, H.A., 1999: A model clinical practice program at Northwestern Memorial Hospital. Medsurg Nursing 8(2): 123-126

Cook D.W.; Canepa C.; Winek T.; Sasaki T.M., 1991: Laryngeal flap for hypopharynx reconstruction. Hypopharynx repair following resection of a pyriform sinus carcinoma may be accomplished primarily or involve a more extensive procedure, such as a free intestinal graft. Described herein is a laryngeal flap which may be used to repair a hypophary...

Jonkers, D.; Stobberingh, E.; de Bruine, A.; Arends, J.W.; Stockbrügger, R., 1997: Evaluation of immunohistochemistry for the detection of Helicobacter pylori in gastric mucosal biopsies. A reliable diagnosis of Helicobacter pylori is important in clinical practice and research. To evaluate sensitivity, specificity and inter-observer variation of three histological staining methods for the diagnosis of intragastric H. pylori bacter...

Arnold, M.F.F.; Caro-Hernandez, P.; Tan, K.; Runti, G.; Wehmeier, S.; Scocchi, M.; Doerrler, W.T.; Walker, G.C.; Ferguson, G.P., 2014: Enteric YaiW is a surface-exposed outer membrane lipoprotein that affects sensitivity to an antimicrobial peptide. yaiW is a previously uncharacterized gene found in enteric bacteria that is of particular interest because it is located adjacent to the sbmA gene, whose bacA ortholog is required for Sinorhizobium meliloti symbiosis and Brucella abortus pathogene...

Pastena, B., 1961: The effect of the position of origin on the percentage of rooting in cuttings from vine rootstocks. Note IV. Correlation between position, diameter and rooting. The rootstocks were those used in previous work plus a further hybrid, 110 Richter. The main shoots were cut into 9, and the laterals into 2, portions. In the combined results rooting was poor from portions 1 and 2 (basal) and 9 (apical) and from...

Hardy R.A.Jr, 1973: Narcotic antagonists and analgesics. Heinzelman, Richard V (Ed ) Annual Reports in Medicinal Chemistry, Vol 8 Xi+356p Illus Academic Press: New York, N Y , U S A ; London, England 20-28