+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Isolation and physicochemical characterization of solid forms of glibenclamide

, : Isolation and physicochemical characterization of solid forms of glibenclamide. International Journal of Pharmaceutics (Kidlington) 50(2): 103-110

Two polymorphs and two pseudo-polymorphs of glibenclamide were obtained by crystallization from a number of solvents. They were characterized by thermal microscopy, differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, infrared spctroscopy, and dynamic and equilibrium solubility studies. Substantial differences were detected between the polymorphs and pseudo-polymorphs. Particularly, the pentanol and toluene solvates were significantly different with regard to dissolution rate and equilibrium solubility from each other and from the two polymorphs.


DOI: 10.1016/0378-5173(89)90134-8

Other references

Jung, J.; Roh, D.; Moon, Y.Sun.; Kim, D.Hoon., 2017: The Moderating Effect of Religion on the Relationship Between Depression and Suicidal Ideation in the Elderly. This article aimed to compare the level of suicidal ideation in the religiously affiliated and nonaffiliated groups and identify the moderating effect of religion variables on the relationship between depression and suicidal ideation. The sample i...

Gallin, R.S., 1984: Rural industrialization and Chinese women: a case study from Taiwan. To maintain political stability and a cheap, elastic labour supply necessary for contemporary capitalism to operate in Taiwan, the Government allocates a large share of its budget to national security, a small share to social welfare infrastructur...

Porkka Heiskanen T.; Laakso M L.; Stenberg D.; Johansson G.; Peder M., 1987: The effect of testosterone on gonadotropin levels of male rats in normal lighting conditions and constant light. Neuroscience 22(SUPPL): S156

Benchetrit, I.; Ocampo, J.C.; Paez, O.J.S., 1965: Comparative study of routine tests and their application to milk classification. Different tests were used for the hygienic classification of the milk, compared with the plate count for determining its efficiency. Two hundred and fifty samples were extracted and 1,171 tests were compared, corresponding to the following determi...

Russell, R.J.; Festing, M.F.; Deeny, A.A.; Peters, A.G., 1993: DNA fingerprinting for genetic monitoring of inbred laboratory rats and mice. DNA fingerprinting using a nonisotopically labeled minisatellite probe provided a valuable technique for genetic monitoring/quality control of laboratory rodents. Each of 12 inbred rat strains had a unique fingerprint pattern, and colonies separat...

A.S.areef A.; Buss D.C.; Shetty H.G.M.; Ali N.; Routledge P.A., 1990: The effect of repeated dose activated charcoal on the pharmacokinetics of sodium valproate in healthy volunteers. British Journal of Clinical Pharmacology 30(2): 331P-332P

Crandall, Keith A., 1997: The crayfish component to an endangered aquatic ecosystem of the southeast United States. Freshwater Crayfish, 11: 83-86

DaniushevskiÄ­, S.M., 1973: Central Commission of the All-Russian Central Executive Committee for Improving the Living Conditions of Workers. Sovetskoe Zdravookhranenie 32(5): 61-66

Corbin, C.B., 2012: C. H. McCloy lecture: fifty years of advancements in fitness and activity research. Over the past 50 years progress in fitness and activity research has been influenced by social events, technical innovations, and changes in the field of physical education and kinesiology. The conventional wisdom of the 1950s yielded to a new wis...

Chuang, J.H.; Wan, Y.L., 1995: Evaluation of pectus excavatum with repeated CT scans. The use of a single CT scan to evaluate the severity of pectus excavatum has been popular since its inception. However, there is no objective data to address the evolution of the deformity. Using repeated CT scans taken an average of 1 year and 3...