geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of evidence of the size principle of selective vulnerability of axons in toxic neuropathies i. the effects of subcutaneous injections of 2 5 hexanedione on behavior and muscle spindle function


, : Lack of evidence of the size principle of selective vulnerability of axons in toxic neuropathies i. the effects of subcutaneous injections of 2 5 hexanedione on behavior and muscle spindle function. Toxicology and Applied Pharmacology 104(1): 47-58

2,5-Hexanedione (HD) produces a central-peripheral distal axonopathy. It has been suggested that agents which produce this type of axonopathy show a predilection to the largest diameter fibers. This has been based primarily on morphological data. However, electrophysiological evidence and some clinical and morphological data suggest that this may not be the case. In particular, in acrylamide neuropathy, muscle spindle primary afferents do not show this selectivity, as well as autonomic fibers. This study was carried out to determine whether the largest diameter axon were selectively vulnerable to HD. We found that subcutaneous injections of HD in cats produced a dose-dependent increase in behavioral deficits such as contact placing, stepping, and locomotion. There was also a dose-dependent decrease in the position sensitivity of muscle spindle primary and secondary endings. However, the secondary endings, which are innervated by smaller axons, were affected prior to the primary endings. Also, the velocity sensitivity of the primary endings was depressed at a similar time frame as the position sensitivity of these same endings. These data are consistent with the hypothesis that the caliber of the axon is not the only determinant of the selective vulnerability of axons in distal axonopathy.

US$29.90

PMID: 2141734


Other references

Aivaliotis, M.; Kontochristopoulos, G.; Hatziolou, E.; Aroni, K.; Zakopoulou, N., 2007: Successful colchicine administration in facial granulomas caused by cosmetic implants: report of a case. Injectable cutaneous microimplants may occasionally cause either persistent local irritation or late skin reactions in the form of foreign body granulomas at the injected areas. Permanent elimination of the latter is not easily achieved. The skin...

Dohaithem, A.; Al-Nasser, A.; Al-Badah, A.; Al-Nazhan, S.; Al-Maflehi, N., 2012: An in vitro evaluation of antifungal activity of bioaggregate. Of this study was to evaluate, in vitro, the antifungal effect of bioaggregate (BA) against Candida albicans by using the direct contact method. Study design: BA was tested freshly mixed and after 24-hour set on C. albicans. The tested BA was incu...

Ogren, S.O., 1992: Selective dopamine D-2 receptor antagonists with an atypical neuroleptic profile. Clinical Neuropharmacology 15 Suppl 1 Pt A: 462a-463a

Mondel, P.Kumar.; Saraf, R.; Limaye, U.S., 2015: Acute subarachnoid hemorrhage in posterior condylar canal dural arteriovenous fistula: imaging features with endovascular management. A 43-year-old man presented with acute subarachnoid hemorrhage. He was investigated and found to have a rare posterior condylar canal dural arteriovenous fistula (DAVF). DAVFs of the posterior condylar canal are rare. Venous drainage of the DAVF w...

Kitazawa, S.; Takenaka, A.; Kondo, T.; Mizoguchi, A.; Kitazawa, R., 2006: Protruding disordered loop of gC1qR is specifically exposed and related to antiapoptotic property in germ cell lineage. We established a monoclonal antibody (MAb), 5G9, with the use of a fixed seminoma tissue from an archival paraffin-embedded specimen, as an immunogen. Without antigen retrieval, positive 5G9-immunohistochemical staining was confined mostly to pri...

Jokic, Z.; Hristov, S.; orevic, N., 2000: Influence of supplemental methionine, choline and magnesium-sulfate in the diet on daily gain weight and efficiency of feed consumption of broiler chickens. The effect of addition of methionine, choline and magnesium sulfate to the basic feed ration (consisting of maize and soyabean meal) on daily weight gain and feed utilization in broilers was studied. In the first period of finishing, the basic fee...

Zhang, Z.; Wu, Z.; Wirth, M.J., 2014: Polyacrylamide brush layer for hydrophilic interaction liquid chromatography of intact glycoproteins. A chromatographic column of nonporous silica particles with a bonded phase of linear polyacrylamide chains is evaluated for hydrophilic interaction liquid chromatography (HILIC) of intact glycoproteins. The column is shown to retain glycoproteins...

Silva, J.; Cerqueira, Fátima.; Ribeiro, J.; Sousa, H.; Osório, T.; Medeiros, R., 2014: Is Chlamydia trachomatis related to human papillomavirus infection in young women of southern European population? A self-sampling study. It is well established the role of human papillomavirus (HPV) in cervical cancer (CC) etiology. Chlamydia trachomatis (CT) infection seems to synergize with HPV in CC multistage process. The aim of this study was to assess the correlation of HPV a...

Damgaard M.; Arlien Soborg P.; Bruhn P.; Christensen E.L., 1981: Chronic painters disease a follow up investigation of the occupational and economical situations of 26 house painters. Follow-up investigation of 26 house painters with toxic encephalopathy revealed that 16 painters had been awarded disability pensions, 8 were still occupationally active and 2 were receiving retraining or education. Two patients applied for disabi...

Vavaev, A.V.; Buriachkivskaia, L.I.; Tishchenko, E.G.; Uchitel', I.A.; Maksimenko, A.V., 2012: Antioxidant and antiaggregant effects of covalent bienzyme superoxide dismutase-chondroitin sulfate-catalase conjugate in platelet interactions. A covalent bienzyme superoxide dismutase-chondroitin sulfate-catalase conjugate (SOD-CHS-CAT) demonstrated the dose-dependent inhibitory action on induced aggregation of platelets in the presence of hydrogen peroxide. Antioxidant activity of SOD-C...