+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Multiple chromosomal changes and karyotypic evolution in a patient with myelofibrosis

, : Multiple chromosomal changes and karyotypic evolution in a patient with myelofibrosis. Cancer Genetics & Cytogenetics 61(1): 6-10

Several subclones were identified in unstimulated peripheral blood cells from a patient with chronic myeloproliferative disease, which was classified as myelofibrosis by morphologic terms. These subclones were characterized by an unusual number of different karyotype anomalies. Some of the more complex chromosomal rearrangements could be clearly defined by fluorescence in situ hybridization. Chromosome arms involved in clonal aberrations were 1q, 3p, 6p, 7q, 11q, 13q, 15q, 17q, 18p, and 20q. Reconstruction of karyotype evolution was attempted by karyotypic analysis of 100 metaphase spreads each in two separate investigations.


PMID: 1638481

DOI: 10.1016/0165-4608(92)90362-c

Other references

Faierman, M.L.; Anderson, J.E.; Assane, A.; Bendix, P.; Vaz, F.; Rose, J.A.; Funzamo, C.; Bickler, S.W.; Noormahomed, E.V., 2015: Surgical patients travel longer distances than non-surgical patients to receive care at a rural hospital in Mozambique. Surgical care is increasingly recognised as an important component of global health delivery. However, there are still major gaps in knowledge related to access to surgical care in low-income countries. In this study, we compare distances travelle...

Chabot N.L.; Campbell A.J.; Humayun M.; Jones J.H.; Lauer H.V., 2005: Distinguishing between sulfur and carbon-bearing metallic liquids during meteorite histories. Meteoritics and Planetary Science 40, Suppl

Agüero-Chapin, Gín.; Varona-Santos, J.; de la Riva, G.A.; Antunes, A.; González-Vlla, Tás.; Uriarte, E.; González-Díaz, H., 2009: Alignment-free prediction of polygalacturonases with pseudofolding topological indices: experimental isolation from Coffea arabica and prediction of a new sequence. Polygalacturonases (PGs) have called the attention of microbiology scientists and biotechnology or pharmaceutical industry because they are protein enzymes relevant to phytopathogens invasion, fruit ripening, and potential antimicrobial drug targe...

Marques, R.J., 1954: Deficiency dermatitis in cirrhosis of the liver. Skin lesions resembling those described in pellagra or vitamin A deficiency were observed in 76 per cent. of patients with cirrhosis of the liver, but were rare in other patients from the same environment. Xerosis. hyperkeratosis and glossitis wer...

Colquhoun, A.J.; Wozniak, S.P.; Tulchinsky, E.M.; Kriajevska, M.; Mellon, J.K., 2004: Can inhibition of epidermal growth factor receptor with gefitinib improve response to ionising radiation in bladder cancer cell lines?. European Urology Supplements 3(2): 207, February

Anonymous, 1921: The Retirement Of Dr. W. H. Jordan. Science 54(1395): 270-271

Bjorkstrand B.; Robert K.H.; Ljunggren H.G., 1990: Proliferation of murine lymphoma cell line rbl 5 is inhibited by a growth factor deprived liquid culture system. Experimental Hematology (Charlottesville) 18(6): 586

Bosley, B.; Rosen, C.A.; Simpson, C.Blake.; McMullin, B.T.; Gartner-Schmidt, J.L., 2006: Medial arytenoidectomy versus transverse cordotomy as a treatment for bilateral vocal fold paralysis. Transverse cordotomy (TC) and medial arytenoidectomy (MA) are procedures performed to enlarge the glottic airway in patients with bilateral vocal fold paralysis (BVFP). Both are less destructive than total arytenoidectomy and have distinct theoret...

Behrens, R.; Dietze, G., 2010: Monitoring the eye lens: which dose quantity is adequate?. Recent epidemiological studies suggest a rather low dose threshold (below 0.5 Gy) for the induction of a cataract of the eye lens. Some other studies even assume that there is no threshold at all. Therefore, protection measures have to be optimize...

Sigh, J.; Buchmann, K., 2000: Host responses towards parasitic ciliates. Acta Parasitologica 45(3): 271, July