+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

NADP+ biosynthesis by rats receiving a pellagragenic diet

, : NADP+ biosynthesis by rats receiving a pellagragenic diet. Brazilian Journal of Medical and Biological Research 24(6): 563-566

Rats showing signs of pellagra-like disease associated with gelatin ingestion were injected with [14C]-nicotinic acid into the portal vein and the incorporation of the label into hepatic NAD+ and NADP+ was determined. The quantity of NADP+ synthesized within 1 h after [14C]-nicotinic acid injection by the experimental group, supplemented or not with dietary niacin, was 75% lower than that synthesized by the control group fed a casein control diet (141 nmol h-1 g-1). The NAD+ and NADP+ contents of the liver of the experimental animals were 245 and 93 micrograms/g liver, respectively, i.e., significantly lower than those for the controls (597 and 210 micrograms/g, respectively). Dietary supplementation with niacin increased the NAD+ content to 317 micrograms/g liver but had no statistical effect on NADP+ content (75 micrograms/g liver) or NADP+ synthesis (46.5 in the free niacin group vs 37.0 nmol h-1 g-1 in the niacin-supplemented group). Therefore, NAD+ content did not seem to limit NADP+ synthesis. These results suggest that the lower availability of NADP+ is responsible, at least in part, for some metabolic derangements in pellagra-like disease, such as a decrease in the activity of NADP(+)-dependent enzymes observed in quail muscle.


PMID: 1823271

Other references

Brown, C.; Moss, J.; Brown, L., 1975: Performance of bulls on Arkansas cooperative beef bull performance test 13. Report series: 75, 222

Gatzek, H.; Mechelke, K., 1949: Effect of beta -pyridylcaibinol on the circulation. The effect of beta -pyridylcarbinol, ronicol, on the circulation was studied by the method of Matthes Deutsch. med. Wochenschr., 1947, 72, 28) in normal subjects with blood samples taken from the ear ^nd the finger tip. The stimulating effect of J...

Moore T.R.; Sorg J.; Miller L.; Key T.G.; Resnik R., 1986: Hemodynamic effects of intravenous cocaine on the pregnant ewe and fetus. Cocaine is a potent vasoconstrictive agent that is currently the subject of widespread drug abuse. Because little is known of the physiologic responses to cocaine in pregnancy, the effects of intravenous cocaine on uterine blod flow and other mate...

Fantini Sestini Nerina, 1962: Contributo allo studio delle ammoniti del domeriano di M. Domaro (Brescia). Describes ammonites from Domerian (Liassic) deposits of Domaro mountain, Brescia, Italy. Among the seven families represented, species belonging to the Hildoceratidae are the most abundant forms. The two upper subzones of the lower Domerian Amalth...

Nascimento, J.L.iz Xavier do.; Flores, J.M.cedo.; Ataguile, B.S.lvador.; Koch, M.; Scherer, S.B.rbosa.; Santos, P.J.rge Parreira dos., 2001: Biological aspects of the black-necked swan Cygnus melancoryphus and Coscoroba swan Coscoroba coscoroba in Rio Grande do Sul state, Brazil. Melopsittacus. January-February-March; 41: 31-38

Ribeiro,F.; Collares-Pereira,M.J., 2010: Life-history variability of non-native centrarchids in regulated river systems of the lower River Guadiana drainage. Life-history variability of two non-native centrarchids, pumpkinseed <i>Lepomis gibbosus</i> and largemouth bass <i>Micropterus salmoides</i>, was evaluated in three stream stretches of the lower River Guadiana drainage (so...

Karasev, M.A., 1955: Nesting of the redstart in the house. Priroda, 12: 116-117

Gupta, A.K.; Chwetzoff, E.; Del Rosso, J.; Baran, R., 2002: Hepatic safety of itraconazole. As the use of the newer oral antifungal agents for the treatment of superficial fungal infections becomes more widespread, the issue of safety surrounding their use is becoming an increasingly important consideration. Itraconazole is effective and...

Schoeller Henri, 1968: Silica in thermal mineral springs of the Pyrenees. Silica in equilibrium with kaolin in waters issuing from shallow depths, silica in equilibrium with sodic feldspars in waters issuing from deep-seated metamorphic and granitic rocks, France.

Aicardi, J., 1972: Diagnosis of hemispheric tumors in children. Revue de Neuropsychiatrie Infantile et D'hygiene Mentale de L'enfance 20(8): 639-651