geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Naphthaloyl group a new selective amino protecting group for deoxynucleosides in oligonucleotide synthesis


, : Naphthaloyl group a new selective amino protecting group for deoxynucleosides in oligonucleotide synthesis. Canadian Journal of Chemistry 66(12): 2989-2994

The naphthaloyl group has been found to be a selective amino protecting group for deoxycytidine, deoxyadenosine, and deoxyguanosine in oligodeoxyribonucleotide synthesis. All three protected monomers obtained (78-85%), being six-membered cyclic imides, were fairly stable. These protected monomers were used successfully for the preparation of dimers (phosphodiester approach) and tetramers (phosphotriester approach) in solution as well as solid phase, respectively. The group acted as a purification tool due to its high lipophilicity. No adverse effect has been observed either on the glycosidic bond (depurination) or the internucleotidic bond during its removal. The monomeric units were characterized by UV, NMR, and elemental analyses whereas the tetramers were characterized by enzymatic hydrolyses with snake venom phosphodiesterase followed by alkaline phosphatase.

US$19.90

DOI: 10.1139/v88-464


Other references

Wohlrab, J., 2011: Dermatologic therapy in pregnancy. Pharmacologic therapy of a pregnant patient requires particular care in selecting the active substances to be used, their dosage and administration. The teratogenic risk and the therapeutic benefit must be carefully weighed for the mother and poss...

Muller, A.F.; Manning, E.L.; Moret, P.; Megevand, R., 1964: Renal blood supply and aldosterone secretion. Bleeding, aortic constriction and renal artery constriction, as well as opening of an A-V fistula, increase selectively the secretion of aldosterone in the normal, stressed, non-hypophysectomized dog. A decreased pulse pressure is therefore not a...

Viel-Thériault, I.; Thibeault, R.; Boucher, F.D.; Drolet, J-Philippe., 2016: Thalidomide in Refractory Tuberculomas and Pseudoabscesses. NlmCategory="UNASSIGNED">Paradoxical immune reconstitution inflammatory syndrome is a well-described entity even in immunocompetent children, principally in association with Mycobacterium tuberculosis infections. Central nervous syste...

Can, B.; Sali, M.; Batman, A.; Yilmaz, H.; Korkmaz, U.; Celebi, A.; Senturk, O.; Hulagu, S., 2015: Valsartan-induced acute pancreatitis. Gastrointestinal toxicity is uncommon among patients treated with angiotensin II receptor antagonists. A 58-year-old man presented with nausea, vomiting and constant pain in the epigastrium that radiated to the flanks. He received treatment with v...

Naik, H.G.; Yeniad, B.; Koning, C.E.; Heise, A., 2012: Investigation of asymmetric alcohol dehydrogenase (ADH) reduction of acetophenone derivatives: effect of charge density. In an effort to study the effect of substituent groups of the substrate on the alcohol dehydrogenase (ADH) reductions of aryl-alkyl ketones, several derivatives of acetophenone have been evaluated against ADHs from Lactobacillus brevis (LB) and Th...

Terheyden, S.; Nederveen-Schippers, L.M.; Kortholt, A., 2016: The unconventional G-protein cycle of LRRK2 and Roco proteins. NlmCategory="UNASSIGNED">Mutations in the human leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of hereditary Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins, which are characterized by the...

Voller, E.K.; Long, P.J.; Aosved, A.C., 2008: Attraction to sexual violence towards women, sexual abuse of children, and non-sexual criminal behavior: testing the specialist vs. generalist models in male college students. A sample of 492 college men anonymously completed an expanded version of the Sexual Experiences Survey, the revised Attraction to Sexual Aggression Scale, and the Marlowe-Crowne Social Desirability Scale Short Form to investigate the relations amo...

Wilkins, H.D.wn; Ritchison, G., 1999: Drumming and tapping by Red-bellied Woodpeckers: Description and possible causation. Although drumming (striking the substrate with the bill rapidly and repetitively) and tapping (striking the substrate regularly and at slower rates) are thought to play important roles in woodpecker communication, questions remain concerning the s...

Powelson R.L.; Young S.A., 1977: Efficacy of commercial applications of benomyl for control of cercosporella pseudocercosporella foot rot of wheat. Proceedings of the American Phytopathological Society (4): 210

Blitz, M.; Spivack, E.; Kerpel, S.M.; Freedman, P.D., 2003: Stevens-Johnson syndrome in an HIV-infected patient. Stevens-Johnson syndrome (SJS) is a severe and sometimes lethal form of erythema multiforme most often associated with a drug hypersensitivity reaction. HIV-infected patients suffer a higher incidence of SJS than the general population. This artic...