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Persistent decreased fibrinolytic activity in cyclosporin treated renal allograft recipients


, : Persistent decreased fibrinolytic activity in cyclosporin treated renal allograft recipients. Fibrinolysis 2(4): 197-202

Cyclosporin (CS) may enhance or accelerate vascular endothelial injury. Both tissue plasminogen activator (t-PA) and its fast acting inhibitor (PAI-1) are synthesized and released by the vascular endothelium and regulate fibrinolytic activity. Parameters of plasma fibrinolytic activity were assessed serially for 1 year in 21 renal allograft recipients receiving long term immunosuppression with CS and low dose prednisolone. Fibrinolytic activity assessed by euglobulin clot lysis times and fibrin plate assays was significantly decreased from 1 month onwards (p < 0.02 and < 0.002 at 2 months and 1 year and p < 0.002 and < 0.002 at 1 month and 1 year post-transplantation respectively) compared with normal controls. In contrast, tissue plasminogen activator (t-PA) antigen levels were significantly increased, p < 0.02 and < 0.002 at 1 month and 1 year respectively. Tissue plasminogen activator inhibitor (PAI-1) activity was also significantly increased up to 6 months post-transplantation, p < 0.02 and < 0.02 at 1 and 6 months post-transplantation. Thus, CS-treated renal allograft recipients exhibited chronic prothrombotic fibrinolytic changes. The decreased fibrinolytic activity, which persisted even when through whole blood CS levels were within the therapeutic range and plasma creatinine levels were approaching or were in the normal ranges, was probably attributable to increased levels of PAI-1 complexing to and inactivating t-PA released from the vascular endothelium.

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Chu Xuelei; Zhang Tonggang; Zhang Qirui; Lyons Timothy W., 2007: Sulfur and carbon isotope records from 1700 to 800 Ma carbonates of the Jixian section, northern China; implications for secular isotope variations in Proterozoic sea water and relationships to global supercontinental events. This study is a comprehensive, stable isotope survey of the marine carbonate-dominated, upper Paleo- to lower Neoproterozoic stratigraphy of Jixian County, China. Carbonate-associated sulfate (CAS) was extracted and measured for delta (super 34) S...

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Moncrieff, P., 1929: New Zealand Saddlebacks (Creadion carunculatus). New Zealand Journal of Science and Technology, 10: 338-342

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Thum, E., 1979: Automation in the milking process. Agrartechnik 29(2): 50-52

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