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Predictors of arteriographically defined coronary stenosis in the honolulu heart program


, : Predictors of arteriographically defined coronary stenosis in the honolulu heart program. American Journal of Epidemiology 134(2): 111-122

The purpose of this study was to determine if the major risk factors for clinical myocardial infarction also predicted coronary artery stenosis as defined by arteriography. Of a cohort of 7,591 men who were free of cardiovascular disease at entry, 357 had arteriographic studies during a 20-year follow-up period. Risk factor levels were therefore known prior to the onset of clinical symptoms and arteriographic studies. Men with arteriograms were divided into groups with and without prior clinical myocardial infarction. High blood pressure, serum cholesterol, obesity, and low alcohol intake predicted both severe coronary stenosis and incident myocardial infarction, thus indicating that these variables were associated with clinical events through the underlying process of atherosclerosis. Dietary intake of cholesterol and serum glucose also had similar but not always statistically significant patterns of assocation with both coronary stensosis and myocardial infarction. In contrast, serum triglyceride and cigarette smoking predicted clinical myocardial infarction, but not severe coronary stenosis. This suggests that these variables play a stronger role in the precipitation of acute clinical events than in the underlying process of atherosclerosis. The findings were quite different for several risk factors when analyzed in a case-control format using the artriography series from this same data set. Examination of possible explanations for the differences raises questions concerning the use of arteriography series for etiologic studies of coronary atherosclerosis.

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Other references

Soutschek, A.; Schubert, T., 2013: Domain-specific control mechanisms for emotional and nonemotional conflict processing. Recent neuroimaging studies suggest that the human brain activates dissociable cognitive control networks in response to conflicts arising within the cognitive and the affective domain. The present study tested the hypothesis that nonemotional and...

Banfi, A.; Benatena, H.N., 1953: The influence of the rootstock on important biochemical factors in citrus fruit. Part II. Valencia Late orange. Studies were made of the fruit (colour, yield and weight per fruit) and juice (weight, colour, and chemical composition) of Valencia Late on sweet orange, trifoliate orange, rough lemon, Rangpur lime, common mandarin, sour orange, grapefruit, Pers...

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Gregory C.A.; Anderson I.M.; Cowen P.J., 1990: Metergoline abolishes the prolactin response to buspirone. Pretreatment of nine healthy subjects with the non-selective 5-HT receptor antagonist, metergoline (4 mg), abolished the increase in plasma prolactin produced by the anxiolytic drug, buspirone (15 mg). While these findings are consistent with a ro...

Shanghai Collaborative Study Group, 1992: A prospective study on the effect of nifedipine of the cardiovascular complications in the elderly hypertensives. The purpose of this single-blind, placebo-controlled trial was to assess whether long-term treatment with nifedipine can have a beneficial preventive effect on the cardiovascular complications in the elderly hypertensives. Randomization took place...

Kano Sueoka T.; Errick J.E., 1982: Roles of phosphoethanolamine ethanolamine and prolactin in mammary cell growth. Sato, G H , A B Pardee And D A Sirbasku (Ed ) Cold Spring Harbor Conferences on Cell Proliferation, Vol 9 Growth Of Cells in Hormonally Defined Media, Part A And B Xxxi+624p (Part A); Xvii+586p (Part B) Cold Spring Harbor Laboratory: Cold Spring Harbor, N Y , Usa Illus P729-740

Messenger, P.S.; Flitters, N.E., 1958: Effect of constant temperature environments on the egg stage of three species of Hawaiian fruit flies. Eggs of Dacus dorsalis, D. curcurbitae, and Ceratitls capitata (Tephritidae, Diptera) were incubated in constant temperature water baths and the time required to hatch was observed. At any given temperature the distribution of the number of eggs i...

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