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Proliferative membranopathy and human immunodeficiency virus in AIDS hearts


, : Proliferative membranopathy and human immunodeficiency virus in AIDS hearts. Journal of Acquired Immune Deficiency Syndromes 2(2): 129-135

In order to determine if cardiac tissue from AIDS patients or patients with seropositivity to HIV-1 might be infected by HIV-1, portions of myocardium obtained postmortem were evaluated for HIV-1 DNA sequences. Cellular DNA was extracted and digested with EcoR1 and Southern blots were performed. One of three AIDS hearts was positive for HIV-1 DNA sequences without amplification, whereas two additional hearts were positive for HIV-1 DNA after amplification. Accordingly, other tissue from the heart positive for HIV-1 without amplification was studied by electron microscopy to localize HIV virions. Unexpectedly, large numbers of proliferating multilamellated membrane bodies were identified in myocytes, predominantly associated with mitochondria. Identical membrane bodies were found in two additional AIDS hearts, and in one heart from a patient with seropositivity to the AIDS virus, but in none of three similarly fixed controls. Immunocytochemistry for HIV core (p24) and envelope (gp120) antigens did not localize gold-labeled antibodies to the membrane bodies. We believe this membranopathy may be an HIV-1- or AIDS-specific abnormality of unknown etiology that may be related to the ultimate development of cardiomyopathy. In addition, our studies provide further support that HIV-1 may be present in AIDS hearts, although as yet we cannot state with certainty where the HIV-1 is located in these tissues.

US$29.90

PMID: 2539451


Other references

Davison J.M.; Dellagrammatikas H.; Parkin J.M., 1985: Maternal azathioprine therapy and depressed hemopoiesis in the babies of renal allograft patients. Maternal immunosuppression with azathioprine during pregnancy can depress fetal hemopoiesis resulting in neonatal thrombocytopenia and leukopenia with the potential for serious sequelae. The effect on the infant of adjusting azathioprine dosage on...

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Keefe, R.S.E., 2003: The evaluation of cognitive dysfunctions in schizophrenia. L'encephale 28 Spec No 2 Pt 2: S11-S13

Grassi, C., 1965: Review on tuberculosis in old age. Giornale di Gerontologia 13(11): 1313-1322

Jeong, S.; Kang, W.-Soo; Shin, M., 2013: Improvement of the quality of gluten-free rice pound cake using extruded rice flour. To improve the quality of gluten-free rice pound cake (GRPC), the Hanarum extruded rice flours (HERFs) prepared with 250 rpm screw speed, 160 C barrel temperature, and 24 and 30% feed moisture of Hanarum rice flour (HRF) were used. HERF addition r...

Martin, J.R., 1972: Neonatal hypoglycaemia: a proposed scheme of detection and treatment. New Zealand Medical Journal 75(480): 287-290

Hunter, E.G., 2008: Beyond death: inheriting the past and giving to the future, transmitting the legacy of one's self. This study explores the phenomenon of legacy as a component of the aging experience among women. Against a backdrop of prior focus on transmission of material possessions as the primary form of legacy, the concept is critically examined in develop...

Kinzelbach, R., 1972: Einschleppung und Einwanderung von Wirbellosen in Ober-und Mittelrhein. Zeitschrift rhein naturf Ges Mainz ll, 109-150

Nettevich, E.D., 1977: Prospects for the cultivation and breeding of spring wheat. A discussion is presented of problems in breeding varieties suitable for cultivation in the nonchernozem zone of the USSR. Some promising varieties are mentioned.

Falk, O.; Palonek, E.; Björkhem, I., 1988: Effect of ethanol on the ratio between testosterone and epitestosterone in urine. The testosterone/epitestosterone weight ratio in urine is used to detect cases of doping when an athlete has treated himself with exogenous testosterone. When this ratio exceeds 6, it is considered evidence of testosterone doping. We show here tha...