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Reactivity and action mechanism of triazenes vi. triazenes and diazo compounds as modulators of replicative and repair dna synthesis


, : Reactivity and action mechanism of triazenes vi. triazenes and diazo compounds as modulators of replicative and repair dna synthesis. Khimiko Farmatsevticheskii Zhurnal 23(4): 396-398

To study new aspects of the mechanism of antitumor action displayed by triazenes, a number of diazo- and triazenoderivatives were synthesized and tested in vitro for effects on DNA replicative and repair synthesis of human lymphocytes. Triazenes were shown to possess a direct modulatory (inhibitory or stimulant) action on the biochemical processes under study.

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